Headline

Die Forschungsgruppen des TKFIs publizieren in international anerkannten Peer-Review Journalen. Die gelisteten Veröffentlichungen unterstreichen die Vernetzung der onkologisch ausgerichteten Projekte und der GrundlagenforscherInnen mit lokalen und internationalen Universitätskliniken sowie Universitäten.

Viele dieser Veröffentlichungen werden durch kompetitiv vergebene Drittmittelprojekte gefördert, die unter anderem von FWF (Fonds zur Förderung der wissenschaftlichen Forschung), von der FFG (Österreichische Forschungsförderungsgesellschaft mbH) oder vom europäischen H2020 (Horizon 2020) -Programm bereitgestellt werden.

2024

  • Kugler V., Schwaighofer S., Feichtner A., Enzler F., Fleischmann J., Strich S., Schwarz S., Wilson R., Tschaikner P., Troppmair J., Sexl V., Meier P., Kaserer T. & Stefan E. Impact of protein and small molecule interactions on kinase conformations. Elife, 13:RP94755. (2024).
  • Morgenstern-Kaplan D., Kareff S. A., Trabolsi A., Rodriguez E., Krause H., Ribeiro J. R., Tan H., Antonarakis E. S., Lou E., Nagasaka M., Algaze S., Lenz H. J., Liu S. V., Halmos B., Hoon D. S. B., Seeber A., Ma P. C., El-Deiry W. S., Vanderwalde A. M. & Lopes G. Genomic, immunologic, and prognostic associations of TROP2 (TACSTD2) expression in solid tumors. Oncologist, 10:oyae168. Epub ahead of print. (2024).
  • Benjamin-Zukerman T., Shimon G., Gaine M. E., Dakwar A., Peled N., Aboraya M., Masri-Ismail A., Safadi-Safa R., Solomon M., Lev-Ram V., Rissman R. A., Mayrhofer J. E., Raffeiner A., Mol M. O., Argue B. M. R., McCool S., Doan B., van Swieten J., Stefan E., Abel T. & Ilouz R. A mutation in the PRKAR1B gene drives pathological mechanisms of neurodegeneration across species. Brain, 14:awae154 Epub ahead of print. (2024).
  • Wolf D. & Pircher A. Targeting metabolic dependencies in JAK2-V617F-driven MPNs. Blood Adv., 8(9):2310-2311. (2024).
  • Salcher S., Heidegger I., Untergasser G., Fotakis G., Scheiber A., Martowicz A., Noureen A., Krogsdam A., Schatz C., Schäfer G., Trajanoski Z., Wolf D., Sopper S. & Pircher A. Comparative analysis of 10X Chromium vs. BD Rhapsody whole transcriptome single-cell sequencing technologies in complex human tissues. Heliyon, 10(7):e28358. (2024).
  • Feichtner A., Enzler F., Kugler V., Hoppe K., Mair S., Kremser L., Lindner H., Huber R. G., Stelzl U., Stefan E. & Torres-Quesada O. Phosphorylation of the compartmentalized PKA substrate TAF15 regulates RNA-protein interactions. Cell Mol Life Sci., 81(1):162. (2024).
  • Hoppe N., Harrison S., Hwang S. H., Chen Z., Karelina M., Deshpande I., Suomivuori C. M., Palicharla V. R., Berry S. P., Tschaikner P., Regele D., Covey D. F., Stefan E., Marks D. S., Reiter J. F., Dror R. O., Evers A. S., Mukhopadhyay S. & Manglik A. GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway. Nat Struct Mol Biol., 31(4):667-677. Epub (2024).
  • Flygt H., Söderlund S., Richter J., Saussele S., Koskenvesa P., Stenke L., Mustjoki S., Dimitrijevic A., Stentoft J., Majeed W., Roy L., Wolf D., Dreimane A., Gjertsen B. T., Gedde-Dahl T., Ahlstrand E., Markevärn B., Hjorth-Hansen H., Janssen J. & Olsson-Strömberg U. Treatment-free remission after a second TKI discontinuation attempt in patients with Chronic Myeloid Leukemia re-treated with dasatinib – interim results from the DAstop2 trial. Leukemia, 38(4):781-787. Epub (2024).
  • Massri M., Toonen E. J. M., Sarg B., Kremser L., Grasse M., Fleischer V., Torres-Quesada O., Hengst L., Skjoedt M. O., Bayarri-Olmos R., Rosbjerg A., Garred P., Orth-Höller D., Prohászka Z. & Würzner R. Complement C7 and clusterin form a complex in circulation. Front Immunol., 15:1330095. (2024).
  • Juen F., Glänzer D., Plangger R., Kugler V., Fleischmann J., Stefan E., Case D. A., Kovacs H., Kwaku Dayie T. & Kreutz C. Enhanced TROSY Effect in [2-19 F, 2-13 C] Adenosine and ATP Analogs Facilitates NMR Spectroscopy of Very Large Biological RNAs in Solution. Angew Chem Int Ed Engl., e202316273. (2024).

2023

  • Bernkop-Schnürch A. D., Chavooshi D., Descher H. A., Leitner D., Talasz H., Hermann M., Wurst K., Hohloch S., Gust R. & Kircher B. Design, Synthesis, Electrochemical, and Biological Evaluation of Fluorescent Chlorido[N,N‘-bis(methoxy/hydroxy)salicylidene-1,2-bis(4-methoxyphenyl)ethylenediamine]iron(III) Complexes as Anticancer Agents. J Med Chem., 66(23):15916-15925. (2023).
  • Ayvazyan A., Deutsch L., Zidorn C., Kircher B. & Çiçek S. S. Cytotoxic diterpenoids from Salvia glutinosa and comparison with the tanshinone profile of danshen (Salvia miltiorrhiza). Front Plant Sci., 14:1269710. (2023).
  • Koeck S., Amann A., Kern J., Zwierzina M., Lorenz E., Sopper S., Zwierzina H., Mildner F., Sykora M., Sprung S., Hackl H., Augustin F., Maier H. T., Pircher A., Pall G., Wolf D. & Gamerith G. Whole stromal fibroblast signature is linked to specific chemokine and immune infiltration patterns and to improved survival in NSCLC. Oncoimmunology, 12(1):2274130. (2023).
  • Rensing-Ehl A., Lorenz M. R., Führer M., Willenbacher W., Willenbacher E., Sopper S., Abinun M., Maccari M. E., König C., Haegele P., Fuchs S., Castro C., Kury P., Pelle O., Klemann C., Heeg M., Thalhammer J., Wegehaupt O., Fischer M., Goldacker S., Schulte B., Biskup S., Chatelain P., Schuster V., Warnatz K., Grimbacher B., Meinhardt A., Holzinger D., Oommen P. T., Hinze T., Hebart H., Seeger K., Lehmberg K., Leahy T. R., Claviez A., Vieth S., Schilling F. H., Fuchs I., Groß M., Rieux-Laucat F., Magerus A., Speckmann C., Schwarz K. & Ehl S & ALPS study group. Abnormal biomarkers predict complex FAS or FADD defects missed by exome sequencing. J Allergy Clin Immunol., S0091-6749(23)01462-8. (2023).
  • Cucchiaro A., Scherfler A., Corinti D., Berden G., Oomens J., Wurst K., Gust R., Crestoni M. E., Kircher B. & Cziferszky M. Amino Acids as Chelating Ligands for Platinum: Enhanced Stability in an Aqueous Environment Promoted by Biocompatible Molecules. J Med Chem., Epub ahead of print. (2023).
  • Probst H. C , Stoitzner P., Amon L., Backer R. A., Brand A., Chen J., Clausen B. E., Dieckmann S., Dudziak D., Heger L., Hodapp K., Hornsteiner F., Hovav A. H., Jacobi L., Ji X., Kamenjarin N., Lahl K., Lahmar I., Lakus J., Lehmann C. H. K., Ortner D., Picard M., Roberti M. P., Rossnagel L., Saba Y., Schalla C., Schlitzer A., Schraml B. U., Schütze K., Seichter A., Seré K., Seretis A., Sopper S., Strandt H., Sykora M. M., Theobald H., Tripp C. H. & Zitvogel L. Guidelines for DC preparation and flow cytometry analysis of mouse nonlymphoid tissues. Eur J Immunol., 53(11):e2249819. (2023).
  • Rauchenwald T., Handle F., Connolly C. E., Degen A., Seifarth C., Hermann M., Tripp C. H., Wilflingseder D., Lobenwein S., Savic D., Pölzl L., Morandi E. M., Wolfram D., Skvortsova I. I., Stoitzner P., Haybaeck J., Konschake M., Pierer G. & Ploner C. Preadipocytes in human granulation tissue: role in wound healing and response to macrophage polarization. Inflamm Regen., 43(1):53. (2023).
  • Costacurta F., Dodaro A., Bante D., Schöppe H., Sprenger B., Moghadasi S. A., Fleischmann J., Pavan M., Bassani D., Menin S., Rauch S., Krismer L., Sauerwein A., Heberle A., Rabensteiner T., Ho J., Harris R. S., Stefan E., Schneider R., Kaserer T., Moro S., von Laer D. & Heilmann E. A comprehensive study of SARS-CoV-2 main protease (Mpro) inhibitor-resistant mutants selected in a VSV-based system. bioRxiv [Preprint], 09.22.558628. (2023).
  • Isfort S., Manz K., Teichmann L. L., Crysandt M., Burchert A., Hochhaus A., Saussele S., Kiani A., Göthert J. R., Illmer T., Schafhausen P., Al-Ali H. K., Stegelmann F., Hänel M., Pfeiffer T., Giagounidis A., Franke G. N., Koschmieder S., Fabarius A., Ernst T., Warnken-Uhlich M., Wolber U., Kohn D., Pfirrmann M., Wolf D., Brümmendorf T. H. & German CML study group. Step-in dosing of bosutinib in pts with chronic phase chronic myeloid leukemia (CML) after second-generation tyrosine kinase inhibitor (TKI) therapy: results of the Bosutinib Dose Optimization (BODO) Study. Ann Hematol., 102(10):2741-2752. (2023)
  • Moesslacher C. S., Auernig E., Woodsmith J., Feichtner A., Jany-Luig E., Jehle S., Worseck J. M., Heine C. L., Stefan E. & Stelzl U. Missense variant interaction scanning reveals a critical role of the FERM domain for tumor suppressor protein NF2 conformation and function. Life Sci Alliance, 6(8):e202302043. (2023).
  • Kugler V., Lieb A., Guerin N., Donald B. R., Stefan E. & Kaserer T. Disruptor: Computational identification of oncogenic mutants disrupting protein-protein and protein-DNA interactions. Commun Biol., 6(1):720. (2023).
  • Zimmer K., Kocher F., Untergasser G., Kircher B., Amann A., Baca Y., Xiu J., Korn W. M., Berger M. D., Lenz H. J., Puccini A., Fontana E., Shields A. F., Marshall J. L., Hall M., El-Deiry W. S., Hsiehchen D., Macarulla T., Tabernero J., Pichler R., Khushman M., Manne U., Lou E., Wolf D., Sokolova V., Schnaiter S., Zeimet A. G., Gulhati P., Widmann G. & Seeber A. PBRM1 mutations might render a subtype of biliary tract cancers sensitive to drugs targeting the DNA damage repair system. NPJ Precis Oncol., 7(1):64. (2023).
  • Fleischmann J., Schwaighofer S., De Falco L., Enzler F., Feichtner A., Kugler V., Tschaikner P., Huber R. G. & Stefan E. Tracking and blocking interdependencies of cellular BRAF-MEK oncokinase activities. PNAS Nexus, 2(6):pgad185. (2023).
  • Hoppe N., Harrison S., Hwang S. H., Chen Z., Karelina M., Deshpande I., Suomivuori C. M., Palicharla V. R., Berry S. P., Tschaikner P., Regele D., Covey D. F., Stefan E., Marks D. S., Reiter J., Dror R. O., Evers A. S., Mukhopadhyay S. & Manglik A. GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway. bioRxiv [Preprint], 2023.05.23.540554. (2023).
  • Tien Anh, D., Hai Nam, N., Kircher, B. & Baecker, D. The Impact of Fluorination on the Design of Histone Deacetylase Inhibitors. Molecules, 28(4):1973. (2023).
  • Descher, H., Strich, S. L., Hermann, M., Enoh, P., Kircher, B. & Gust R. Investigations on the Influence of the Axial Ligand in [Salophene]iron(III) Complexes on Biological Activity and Redox Behavior. Int J Mol Sci, 24(3):2173. (2023).
  • Ma, B. N., Baecker, D., Descher, H., Brandstaetter, P., Hermann, M., Kircher, B. & Gust, R. Synthesis and biological evaluation of salophen nickel(II) and cobalt(III) complexes as potential anticancer compounds. Arch Pharm (Weinheim), e2200655. Epub ahead of print. (2023).
  • Pichler R., Siska P. J., Tymoszuk P., Martowicz A., Untergasser G., Mayr R., Weber F., Seeber A., Kocher F., Barth D. A., Pichler M. & Thurnher M. A chemokine network of T cell exhaustion and metabolic reprogramming in renal cell carcinoma. Front Immunol, 14:1095195. (2023).
  • Zolotovskaia M. A., Modestov A. A., Suntsova M. V., Rachkova A. A., Koroleva E. V., Poddubskaya E. V., Sekacheva M. I., Tkachev V. S., Garazha A. V., Glusker A. A., Seryakov A. P., Vladimirova U. S., Rumiantsev P. O., Moisseev A. A., Zharkov D. O., Kuzmin D. V., Zhao X., Prassolov V. S., Shegay P. V., Li X., Steinbichler T. B., Kim E., Sorokin M. I., Wang Y. & Buzdin A. A. Pan-cancer antagonistic inhibition pattern of ATM-driven G2/M checkpoint pathway vs other DNA repair pathways. DNA Repair (Amst), 123:103448. (2023).
  • Savic, D., Steinbichler, T. B., Ingruber, J., Negro, G., Aschenbrenner, B., Riechelmann, H., Ganswindt, U., Skvortsov, S., Dudás, J. & Skvortsova, I. I. Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis. Cells, 12(2):336. (2023).

2022

  • Probst, H. C., Stoitzner, P., Amon, L., Backer, R. A., Brand, A., Chen, J., Clausen, B. E., Dieckmann, S., Dudziak, D., Heger, L., Hodapp, K., Hornsteiner, F., Hovav, A. H., Jacobi, L., Ji, X., Kamenjarin, N., Lahl, K., Lahmar, I., Lakus, J., Lehmann, C. H. K., Ortner, D., Picard, M., Roberti, M. P., Rossnagel, L., Saba, Y., Schalla, C., Schlitzer, A., Schraml, B. U., Schütze, K., Seichter, A., Seré, K., Seretis, A., Sopper, S., Strandt, H., Sykora, M. M., Theobald, H., Tripp, C. H. & Zitvogel, L. Guidelines for DC preparation and flow cytometry analysis of mouse nonlymphoid tissues. Eur J Immunol, Epub ahead of print. (2022).
  • Jöhrer, K., Galarza Pérez M., Kircher, B. & Çiçek, S. S. Flavones, Flavonols, Lignans, and Caffeic Acid Derivatives from Dracocephalum moldavica and Their In Vitro Effects on Multiple Myeloma and Acute Myeloid Leukemia. Int J Mol Sci., 23(22):14219. (2022).
  • Torres-Quesada O., Strich S. & Stefan E. Kinase perturbations redirect mitochondrial function in cancer. Bioenerg Commun, 2022:17. (2022).
  • Salcher, S., Sturm, G., Horvath, L., Untergasser, G., Kuempers, C., Fotakis, G., Panizzolo, E., Martowicz, A., Trebo, M., Pall, G., Gamerith, G., Sykora, M., Augustin, F., Schmitz, K., Finotello, F., Rieder, D., Perner, S., Sopper, S., Wolf, D., Pircher, A. & Trajanoski, Z. High-resolution single-cell atlas reveals diversity and plasticity of tissue-resident neutrophils in non-small cell lung cancer. Cancer Cell, 40(12):1503-1520.e8. (2022).
  • Guerin, N., Feichtner, A., Stefan, E., Kaserer, T. & Donald, B. R. Resistor: An algorithm for predicting resistance mutations via Pareto optimization over multistate protein design and mutational signatures. Cell Syst,13(10):830-843.e3. (2022).
  • Piesik, D., Bocianowski, J., Kotwica, K., Lemańczyk, G., Piesik, M., Ruzsanyi, V. & Mayhew, C. A. Responses of Adult Hypera rumicis L. to Synthetic Plant Volatile Blends. Molecules, 27(19):6290. (2022).
  • Torres-Quesada, O., Doerrier, C., Strich, S., Gnaiger, E. & Stefan, E. Physiological Cell Culture Media Tune Mitochondrial Bioenergetics and Drug Sensitivity in Cancer Cell Models. Cancers (Basel), 14(16):3917. (2022).
  • Greier, M. C., Runge, A., Dudas, J., Pider, V., Skvortsova, I. I., Savic, D. & Riechelmann, H. Mitochondrial dysfunction and epithelial to mesenchymal transition in head neck cancer cell lines. Sci Rep., 12(1):13255. (2022).
  • Ślefarska-Wolak, D., Heinzle, C., Leiherer, A., Ager, C., Muendlein, A., Mezmale, L., Leja, M., Corvalan, A. H., Drexel, H., Królicka, A., Shani, G., Mayhew, C. A., Haick, H. & Mochalski, P. Volatilomic Signatures of AGS and SNU-1 Gastric Cancer Cell Lines. Molecules, 27(13):4012. (2022).
  • Ingruber, J., Dudás, J., Savic, D., Schweigl, G., Steinbichler, T. B., Greier, M. D. C., Santer, M., Carollo, S., Trajanoski, Z. & Riechelmann, H. EMT-related transcription factors and protein stabilization mechanisms involvement in cadherin switch of head and neck squamous cell carcinoma. Exp Cell Res., 414(1):113084. (2022).
  • Mochalski, P., King, J., Mayhew, C. A. & Unterkofler, K. Modelling of Breath and Various Blood Volatilomic Profiles-Implications for Breath Volatile Analysis. Molecules, 27(8):2381. (2022).
  • Wolf, D. & Baier, G. IFNγ Helps CBLB-Deficient CD8+ T Cells to Put Up Resistance to Tregs. Cancer Immunol Res., 10(4):370. (2022).
  • Piesik, D., Lemańczyk, G., Bocianowski, J., Buszewski, B., Vidal, S. & Mayhew, C. A. Induction of volatile organic compounds in Triticum aestivum (wheat) plants following infection by different Rhizoctonia pathogens is species specific. Phytochemistry, 198:113162. (2022).
  • Goetzfried, S. K., Kapitza, P., Gallati, C. M., Nindl, A., Cziferszky, M., Hermann, M., Wurst, K., Kircher, B. & Gust, R. Investigations of the reactivity, stability and biological activity of halido (NHC)gold(I) complexes. Dalton Trans, 51(4):1395-1406. (2022).
  • Feichtner, A., Kugler, V., Schwaighofer, S., Nuener, T., Fleischmann, J. & Stefan E. Tracking mutation and drug-driven alterations of oncokinase conformations. Memo, 15(2):137-142. (2022).
  • Fiegl, H., Hagenbuchner, J., Kyvelidou, C., Seeber, B., Sopper, S., Tsibulak, I., Wieser, V., Reiser, E., Roessler, J., Huhtinen, K., Carpén, O., Parson, W., Sprung, S., Marth, C., Ausserlechner M. J. & Zeimet, A. G. Dubious effects of methadone as an “anticancer” drug on ovarian cancer cell-lines and patient-derived tumor-spheroids. Gynecol Oncol., 165(1):129-136. (2022).

2021

  • Henderson, B., Slingers, G., Pedrotti, M., Pugliese, G., Malásková, M., Bryant, L., Lomonaco, T., Ghimenti, S., Moreno, S., Cordell, R., Harren, F. J. M., Schubert, J., Mayhew, C. A., Wilde, M., Di Francesco, F., Koppen, G., Beauchamp, J. D. & Cristescu, S. M. The peppermint breath test benchmark for PTR-MS and SIFT-MS. J Breath Res., (2021).
  • Heine, A., Holderried, T. A. W. & Wolf, D. ROCKing Chronic Graft-Versus-Host Disease. J Clin Oncol., 39(29):3308. (2021).
  • Pezzè, L., Meškytė, E. M., Forcato, M., Pontalti, S., Badowska, K. A., Rizzotto, D., Skvortsova, I. I., Bicciato, S. & Ciribilli, Y. ETV7 regulates breast cancer stem-like cell features by repressing IFN-response genes. Cell Death Dis., 12(8):742. (2021).
  • Naismith, E., Steichen, J., Sopper, S. & Wolf D. NK Cells in Myeloproliferative Neoplasms (MPN). Cancers (Basel), 13(17):4400. (2021).
  • Bohn, J. P., Salcher, S., Pircher, A., Untergasser, G. & Wolf, D. The Biology of Classic Hairy Cell Leukemia. Int J Mol Sci., 22(15):7780. (2021).
  • Kröger, N., Sockel, K., Wolschke, C., Bethge, W., Schlenk, R. F., Wolf, D., Stadler, M., Kobbe, G., Wulf, G., Bug, G., Schäfer-Eckart, K., Scheid, C., Nolte, F., Krönke, J., Stelljes, M., Beelen, D., Heinzelmann, M., Haase, D., Buchner, H., Bleckert, G., Giagounidis, A. & Platzbecker, U. Comparison Between 5-Azacytidine Treatment and Allogeneic Stem-Cell Transplantation in Elderly Patients With Advanced MDS According to Donor Availability (VidazaAllo Study). J Clin Oncol., 39(30):3318-3327. (2021).
  • Boesch, M., Sykora, M., Gasteiger, S., Baty, F., Brutsche, M. H. & Sopper, S. OMIP 077: Definition of all principal human leukocyte populations using a broadly applicable 14-color panel. Cytometry A., 101(1):15-20. (2021).
  • Schanz, O., Cornez, I., Yajnanarayana, S. P., David, F. S., Peer, S., Gruber, T., Krawitz, P., Brossart, P., Heine, A., Landsberg, J., Baier, G. & Wolf, D. Tumor rejection in Cblb-/- mice depends on IL-9 and Th9 cells. J Immunother Cancer, 9(7):e002889. (2021).
  • Mukha, A., Kahya, U., Linge, A., Chen, O., Löck, S., Lukiyanchuk, V., Richter, S., Alves, T. C., Peitzsch, M., Telychko, V., Skvortsov, S., Negro, G., Aschenbrenner, B., Skvortsova, I. I., Mirtschink, P., Lohaus, F., Hölscher, T., Neubauer, H., Rivandi, M., Labitzky, V., Lange, T., Franken, A., Behrens, B., Stoecklein, N. H., Toma, M., Sommer, U., Zschaeck, S., Rehm, M., Eisenhofer, G., Schwager, C., Abdollahi, A., Groeben, C., Kunz-Schughart, L. A., Baretton, G. B., Baumann, M., Krause, M., Peitzsch, C. & Dubrovska, A. GLS-driven glutamine catabolism contributes to prostate cancer radiosensitivity by regulating the redox state, stemness and ATG5-mediated autophagy. Theranostics, 11(16):7844-7868. (2021).
  • Skvortsova, I. Cancer Stem Cells: What Do We Know about Them? Cells, 10(6):1528. (2021).
  • Jöhrer, K. & Ҫiҫek, S. S. Multiple Myeloma Inhibitory Activity of Plant Natural Products. Cancers (Basel), 13(11):2678. (2021).
  • Kripnerová, M., Parmar, H. S., Šána, J., Kopková, A., Radová, L., Sopper, S., Biernacki, K., Jedlička, J., Kohoutová, M., Kuncová, J., Peychl, J., Rudolf, E., Červinka, M., Houdek, Z., Dvořák, P., Houfková, K., Pešta, M., Tůma, Z., Dolejšová, M., Tichánek, F., Babuška, V., Leba, M., Slabý, O. & Hatina, J. Complex Interplay of Genes Underlies Invasiveness in Fibrosarcoma Progression Model. J Clin Med, 10(11):2297. (2021).
  • Orfanoudaki, M., Hartmann, A., Alilou, M., Mehic, N., Kwiatkowski, M., Jöhrer, K., Nguyen Ngoc, H., Hensel, A., Greil, R. & Ganzera, M. Cytotoxic Compounds of Two Demosponges (Aplysina aerophoba and Spongia sp.) from the Aegean Sea. Biomolecules, 11(5):723. (2021).
  • Ploner, C., Rauchenwald, T., Connolly, C. E., Joehrer, K., Rainer, J., Seifarth, C., Hermann, M., Nagl, M., Lobenwein, S., Wilflingseder, D., Cappellano, G., Morandi, E. M. & Pierer, G. Oxidant therapy improves adipogenic differentiation of adipose-derived stem cells in human wound healing. Stem Cell Res Ther., 12(1):280. (2021).
  • Aschenbrenner, B., Negro, G., Savic, D., Sorokin, M., Buzdin, A., Ganswindt, U., Cemazar, M., Sersa, G., Skvortsov, S. & Skvortsova, I. Simvastatin is effective in killing the radioresistant breast carcinoma cells. Radiol Oncol., 55(3):305-316. (2021).
  • Senatore, E., Chiuso, F., Rinaldi, L., Intartaglia, D., Delle Donne, R., Pedone, E., Catalanotti, B., Pirone, L., Fiorillo, B., Moraca, F., Giamundo, G., Scala, G., Raffeiner, A., Torres-Quesada, O., Stefan, E., Kwiatkowski, M., van Pijkeren, A., Morleo, M., Franco, B., Garbi, C., Conte, I. & Feliciello, A. The TBC1D31/praja2 complex controls primary ciliogenesis through PKA-directed OFD1 ubiquitylation. EMBO J., 40(10):e106503. (2021).
  • Fleischmann, J., Feichtner, A., DeFalco, L., Kugler, V., Schwaighofer, S., Huber, R. G. & Stefan, E. Allosteric Kinase Inhibitors Reshape MEK1 Kinase Activity Conformations in Cells and In Silico. Biomolecules, 11(4):518. (2021).
  • Pournejati, R., Gust, R., Sagasser, J., Kircher, B., Jöhrer, K., Ghanbari, M. M. & Karbalaei-Heidari, H. R. In vitro evaluation of cytotoxic effects of di (2-ethylhexyl) phthalate (DEHP) produced by Bacillus velezensis strain RP137 isolated from Persian Gulf. Toxicol In Vitro, 73:105148. (2021).
  • Ҫiҫek, S. S., Willer, J., Preziuso, F., Sönnichsen, F., Greil, R., Girreser, U., Zidorn, C. & Jöhrer, K. Cytotoxic constituents and a new hydroxycinnamic acid derivative from Leontodon saxatilis (Asteraceae, Cichorieae). RSC Adv., 11(18):10489-10496. (2021).
  • Speckbacher, V., Zeilinger, S., Zimmermann, S., Mayhew, C. A., Wiesenhofer, H. & Ruzsanyi, V. Monitoring the volatile language of fungi using gas chromatography-ion mobility spectrometry. Anal Bioanal Chem., 413(11):3055-3067. (2021).
  • Ingruber, J., Savic, D., Steinbichler, T. B., Sprung, S., Fleischer, F., Glueckert, R., Schweigl, G., Skvortsova, I. I., Riechelmann, H. & Dudás, J. KLF4, Slug and EMT in Head and Neck Squamous Cell Carcinoma. Cells, 10(3):539. (2021).
  • Schoepf, A. M., Salcher, S., Obexer, P. & Gust, R. Tackling resistance in chronic myeloid leukemia: Novel cell death modulators with improved efficacy. Eur J Med Chem., 216:113285. (2021).
  • Buzdin, A., Skvortsova, I. I., Li, X. & Wang, Y. Editorial: Next Generation Sequencing Based Diagnostic Approaches in Clinical Oncology. Front Oncol., 10:635555. (2021).
  • Wolf, D. & Pircher, A. Vaccination influenz(a)ing cancer-specific survival. Int J Cancer, 148(8):1806-1807. (2021).
  • Lindner, A. K., Schachtner, G., Tulchiner, G., Thurnher, M., Untergasser, G., Obrist, P., Pipp, I., Steinkohl, F., Horninger, W., Culig, Z. & Pichler, R. Lynch Syndrome: Its Impact on Urothelial Carcinoma. Int J Mol Sci., 22(2):531. (2021).

2020

  • Ratiu, I. A., Ligor, T., Bocos-Bintintan, V., Mayhew, C. A. & Buszewski, B. Volatile Organic Compounds in Exhaled Breath as Fingerprints of Lung Cancer, Asthma and COPD. J Clin Med., 10(1):32. (2020).
  • Pournejati, R., Gust, R., Kircher, B. & Karbalaei-Heidari, H.R. Microindoline 581, an Indole Derivative from Microbacterium Sp. RP581 as A Novel Selective Antineoplastic Agent to Combat Hepatic Cancer Cells: Production, Optimization and Structural Elucidation. Iran J Pharm Res., 19(4):290-305. (2020).
  • Steiner, N., Jöhrer, K., Plewan, S., Brunner-Véber, A., Göbel, G., Nachbaur, D., Wolf, D., Gunsilius, E. & Untergasser, G. The FMS like Tyrosine Kinase 3 (FLT3) Is Overexpressed in a Subgroup of Multiple Myeloma Patients with Inferior Prognosis. Cancers (Basel), 12(9):2341. (2020).
  • Nagl, L., Horvath, L., Pircher, A. & Wolf, D. Tumor Endothelial Cells (TECs) as Potential Immune Directors of the Tumor Microenvironment – New Findings and Future Perspectives. Front Cell Dev Biol., 8:766. (2020).
  • Baecker, D., Kapp, T., Schumacher, P., Gust, R. & Kircher, B. Cell death-inducing properties of selected dendrimers against different breast cancer and leukemia cell lines. Arch Pharm (Weinheim), 353(11):e2000209. (2020).
  • Strashilov, S. A., Yordanov, A. D., Vasileva-Slaveva, M. B. & Konsoulova, A. A. Re-excision within a radius of 2 cm in patients with melanoma of the skin – sufficient for local oncological radicalness. Arch Med Sci., 18(3):690-695. (2020).
  • Steinbichler, T. B., Dudas, J., Ingruber, J., Glueckert, R., Sprung, S., Fleischer, F., Cidlinsky, N., Dejaco, D., Kofler, B., Giotakis, A. I., Skvortsova, I. I. & Riechelmann, H. Slug Is A Surrogate Marker of Epithelial to Mesenchymal Transition (EMT) in Head and Neck Cancer. J Clin Med., 9(7):2061. (2020).
  • Baecker, D., Ma, B. N., Sagasser, J., Schultz, L., Hörschläger, C., Weinreich, M., Steiner, L., Kircher, B. & Gust, R. Amide and ester derivatives of chlorido[4-carboxy-1,2-disalicylideneaminobenzene]iron(iii) as necroptosis and ferroptosis inducers. Dalton Trans., 49(20):6842-6853. (2020).
  • Skvortsova, I. I. & Span, P. N. Editorial: Advances in Biological Understanding of Tumor Radiation Resistance. Front Oncol., 10:754. (2020).
  • Schoepf, A. M., Salcher, S., Hohn, V., Veider, F., Obexer, P. & Gust, R. Synthesis and Characterization of Telmisartan-Derived Cell Death Modulators to Circumvent Imatinib Resistance in Chronic Myeloid Leukemia. ChemMedChem., 15(12):1067-1077. (2020).
  • Mildner, F., Sopper, S., Amann, A., Pircher, A., Pall, G., Köck, S., Naismith, E., Wolf, D. & Gamerith, G. Systematic review: Soluble immunological biomarkers in advanced non-small-cell lung cancer (NSCLC). Crit Rev Oncol Hematol., 153:102948. (2020).
  • Schoepf, A. M., Salcher, S., Obexer, P., Gust, R. Identification and development of non-cytotoxic cell death modulators: Impact of sartans and derivatives on PPARγ activation and on growth of imatinib-resistant chronic myelogenous leukemia cells. Eur J Med Chem., 195:112258. (2020).
  • Arnold, C. R., Mangesius, J., Skvortsova, I. I. & Ganswindt, U. The Role of Cancer Stem Cells in Radiation Resistance. Front Oncol., 10:164. (2020).
  • Negro, G., Aschenbrenner, B., Brezar, S. K., Cemazar, M., Coer, A., Gasljevic, G., Savic, D., Sorokin, M., Buzdin, A., Callari, M., Kvitsaridze, I., Jewett, A., Vasileva-Slaveva, M., Ganswindt, U., Skvortsova, I. & Skvortsov, S. Molecular heterogeneity in breast carcinoma cells with increased invasive capacities. Radiol Oncol., 54(1):103-118. (2020).
  • Jöhrer, K., Stuppner, H., Greil, R. & Çiçek, S. S. Structure-Guided Identification of Black Cohosh (Actaea racemosa) Triterpenoids with In Vitro Activity against Multiple Myeloma. Molecules, 11;25(4):766. (2020).
  • Neuwirt, H., Bouchal, J., Kharaishvili, G., Ploner, C., Jöhrer, K., Pitterl, F., Weber, A., Klocker, H. & Eder, I. E. Cancer-associated fibroblasts promote prostate tumor growth and progression through upregulation of cholesterol and steroid biosynthesis. Cell Commun Signal., 18(1):11. (2020).
  • Borjan, B., Kern, J., Steiner, N., Gunsilius, E., Wolf, D. & Untergasser, G. Spliced XBP1 Levels Determine Sensitivity of Multiple Myeloma Cells to Proteasome Inhibitor Bortezomib Independent of the Unfolded Protein Response Mediator GRP78. Front Oncol., 9:1530. (2020).

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