Headline

The research groups at TKFI publish in international peer-reviewed journals. These publications showcase the interconnection of oncology-focused projects and researchers with both local and international universities and medical centers.

Many of these publications receive funding from competitively awarded third-party projects such as the FWF (Fonds zur Förderung der wissenschaftlichen Forschung), the FFG (Österreichische Forschungsförderungsgesellschaft mbH), and the European H2020 program (Horizon 2020).

2023

  • Tien Anh, D., Hai Nam, N., Kircher, B. & Baecker, D. The Impact of Fluorination on the Design of Histone Deacetylase Inhibitors. Molecules, 28(4):1973. (2023).
  • Descher, H., Strich, S. L., Hermann, M., Enoh, P., Kircher, B. & Gust R. Investigations on the Influence of the Axial Ligand in [Salophene]iron(III) Complexes on Biological Activity and Redox Behavior. Int J Mol Sci, 24(3):2173. (2023).
  • Ma, B. N., Baecker, D., Descher, H., Brandstaetter, P., Hermann, M., Kircher, B. & Gust, R. Synthesis and biological evaluation of salophen nickel(II) and cobalt(III) complexes as potential anticancer compounds. Arch Pharm (Weinheim), e2200655. Epub ahead of print. (2023).
  • Savic, D., Steinbichler, T. B., Ingruber, J., Negro, G., Aschenbrenner, B., Riechelmann, H., Ganswindt, U., Skvortsov, S., Dudás, J. & Skvortsova, I. I. Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis. Cells, 12(2):336. (2023).

2022

  • Probst, H. C., Stoitzner, P., Amon, L., Backer, R. A., Brand, A., Chen, J., Clausen, B. E., Dieckmann, S., Dudziak, D., Heger, L., Hodapp, K., Hornsteiner, F., Hovav, A. H., Jacobi, L., Ji, X., Kamenjarin, N., Lahl, K., Lahmar, I., Lakus, J., Lehmann, C. H. K., Ortner, D., Picard, M., Roberti, M. P., Rossnagel, L., Saba, Y., Schalla, C., Schlitzer, A., Schraml, B. U., Schütze, K., Seichter, A., Seré, K., Seretis, A., Sopper, S., Strandt, H., Sykora, M. M., Theobald, H., Tripp, C. H. & Zitvogel, L. Guidelines for DC preparation and flow cytometry analysis of mouse nonlymphoid tissues. Eur J Immunol, Epub ahead of print. (2022).
  • Jöhrer, K., Galarza Pérez M., Kircher, B. & Çiçek, S. S. Flavones, Flavonols, Lignans, and Caffeic Acid Derivatives from Dracocephalum moldavica and Their In Vitro Effects on Multiple Myeloma and Acute Myeloid Leukemia. Int J Mol Sci., 23(22):14219. (2022).
  • Salcher, S., Sturm, G., Horvath, L., Untergasser, G., Kuempers, C., Fotakis, G., Panizzolo, E., Martowicz, A., Trebo, M., Pall, G., Gamerith, G., Sykora, M., Augustin, F., Schmitz, K., Finotello, F., Rieder, D., Perner, S., Sopper, S., Wolf, D., Pircher, A. & Trajanoski, Z. High-resolution single-cell atlas reveals diversity and plasticity of tissue-resident neutrophils in non-small cell lung cancer. Cancer Cell, 40(12):1503-1520.e8. (2022).
  • Guerin, N., Feichtner, A., Stefan, E., Kaserer, T. & Donald, B. R. Resistor: An algorithm for predicting resistance mutations via Pareto optimization over multistate protein design and mutational signatures. Cell Syst,13(10):830-843.e3. (2022).
  • Piesik, D., Bocianowski, J., Kotwica, K., Lemańczyk, G., Piesik, M., Ruzsanyi, V. & Mayhew, C. A. Responses of Adult Hypera rumicis L. to Synthetic Plant Volatile Blends. Molecules, 27(19):6290. (2022).
  • Torres-Quesada, O., Doerrier, C., Strich, S., Gnaiger, E. & Stefan, E. Physiological Cell Culture Media Tune Mitochondrial Bioenergetics and Drug Sensitivity in Cancer Cell Models. Cancers (Basel), 14(16):3917. (2022).
  • Greier, M. C., Runge, A., Dudas, J., Pider, V., Skvortsova, I. I., Savic, D. & Riechelmann, H. Mitochondrial dysfunction and epithelial to mesenchymal transition in head neck cancer cell lines. Sci Rep., 12(1):13255. (2022).
  • Ślefarska-Wolak, D., Heinzle, C., Leiherer, A., Ager, C., Muendlein, A., Mezmale, L., Leja, M., Corvalan, A. H., Drexel, H., Królicka, A., Shani, G., Mayhew, C. A., Haick, H. & Mochalski, P. Volatilomic Signatures of AGS and SNU-1 Gastric Cancer Cell Lines. Molecules, 27(13):4012. (2022).
  • Ingruber, J., Dudás, J., Savic, D., Schweigl, G., Steinbichler, T. B., Greier, M. D. C., Santer, M., Carollo, S., Trajanoski, Z. & Riechelmann, H. EMT-related transcription factors and protein stabilization mechanisms involvement in cadherin switch of head and neck squamous cell carcinoma. Exp Cell Res., 414(1):113084. (2022).
  • Mochalski, P., King, J., Mayhew, C. A. & Unterkofler, K. Modelling of Breath and Various Blood Volatilomic Profiles-Implications for Breath Volatile Analysis. Molecules, 27(8):2381. (2022).
  • Wolf, D. & Baier, G. IFNγ Helps CBLB-Deficient CD8+ T Cells to Put Up Resistance to Tregs. Cancer Immunol Res., 10(4):370. (2022).
  • Piesik, D., Lemańczyk, G., Bocianowski, J., Buszewski, B., Vidal, S. & Mayhew, C. A. Induction of volatile organic compounds in Triticum aestivum (wheat) plants following infection by different Rhizoctonia pathogens is species specific. Phytochemistry, 198:113162. (2022).
  • Goetzfried, S. K., Kapitza, P., Gallati, C. M., Nindl, A., Cziferszky, M., Hermann, M., Wurst, K., Kircher, B. & Gust, R. Investigations of the reactivity, stability and biological activity of halido (NHC)gold(I) complexes. Dalton Trans, 51(4):1395-1406. (2022).
  • Feichtner, A., Kugler, V., Schwaighofer, S., Nuener, T., Fleischmann, J. & Stefan E. Tracking mutation and drug-driven alterations of oncokinase conformations. Memo, 15(2):137-142. (2022).
  • Fiegl, H., Hagenbuchner, J., Kyvelidou, C., Seeber, B., Sopper, S., Tsibulak, I., Wieser, V., Reiser, E., Roessler, J., Huhtinen, K., Carpén, O., Parson, W., Sprung, S., Marth, C., Ausserlechner M. J. & Zeimet, A. G. Dubious effects of methadone as an “anticancer” drug on ovarian cancer cell-lines and patient-derived tumor-spheroids. Gynecol Oncol., 165(1):129-136. (2022).

2021

  • Henderson, B., Slingers, G., Pedrotti, M., Pugliese, G., Malásková, M., Bryant, L., Lomonaco, T., Ghimenti, S., Moreno, S., Cordell, R., Harren, F. J. M., Schubert, J., Mayhew, C. A., Wilde, M., Di Francesco, F., Koppen, G., Beauchamp, J. D. & Cristescu, S. M. The peppermint breath test benchmark for PTR-MS and SIFT-MS. J Breath Res., (2021).
  • Heine, A., Holderried, T. A. W. & Wolf, D. ROCKing Chronic Graft-Versus-Host Disease. J Clin Oncol., 39(29):3308. (2021).
  • Pezzè, L., Meškytė, E. M., Forcato, M., Pontalti, S., Badowska, K. A., Rizzotto, D., Skvortsova, I. I., Bicciato, S. & Ciribilli, Y. ETV7 regulates breast cancer stem-like cell features by repressing IFN-response genes. Cell Death Dis., 12(8):742. (2021).
  • Naismith, E., Steichen, J., Sopper, S. & Wolf D. NK Cells in Myeloproliferative Neoplasms (MPN). Cancers (Basel), 13(17):4400. (2021).
  • Bohn, J. P., Salcher, S., Pircher, A., Untergasser, G. & Wolf, D. The Biology of Classic Hairy Cell Leukemia. Int J Mol Sci., 22(15):7780. (2021).
  • Kröger, N., Sockel, K., Wolschke, C., Bethge, W., Schlenk, R. F., Wolf, D., Stadler, M., Kobbe, G., Wulf, G., Bug, G., Schäfer-Eckart, K., Scheid, C., Nolte, F., Krönke, J., Stelljes, M., Beelen, D., Heinzelmann, M., Haase, D., Buchner, H., Bleckert, G., Giagounidis, A. & Platzbecker, U. Comparison Between 5-Azacytidine Treatment and Allogeneic Stem-Cell Transplantation in Elderly Patients With Advanced MDS According to Donor Availability (VidazaAllo Study). J Clin Oncol., 39(30):3318-3327. (2021).
  • Boesch, M., Sykora, M., Gasteiger, S., Baty, F., Brutsche, M. H. & Sopper, S. OMIP 077: Definition of all principal human leukocyte populations using a broadly applicable 14-color panel. Cytometry A., 101(1):15-20. (2021).
  • Schanz, O., Cornez, I., Yajnanarayana, S. P., David, F. S., Peer, S., Gruber, T., Krawitz, P., Brossart, P., Heine, A., Landsberg, J., Baier, G. & Wolf, D. Tumor rejection in Cblb-/- mice depends on IL-9 and Th9 cells. J Immunother Cancer, 9(7):e002889. (2021).
  • Mukha, A., Kahya, U., Linge, A., Chen, O., Löck, S., Lukiyanchuk, V., Richter, S., Alves, T. C., Peitzsch, M., Telychko, V., Skvortsov, S., Negro, G., Aschenbrenner, B., Skvortsova, I. I., Mirtschink, P., Lohaus, F., Hölscher, T., Neubauer, H., Rivandi, M., Labitzky, V., Lange, T., Franken, A., Behrens, B., Stoecklein, N. H., Toma, M., Sommer, U., Zschaeck, S., Rehm, M., Eisenhofer, G., Schwager, C., Abdollahi, A., Groeben, C., Kunz-Schughart, L. A., Baretton, G. B., Baumann, M., Krause, M., Peitzsch, C. & Dubrovska, A. GLS-driven glutamine catabolism contributes to prostate cancer radiosensitivity by regulating the redox state, stemness and ATG5-mediated autophagy. Theranostics, 11(16):7844-7868. (2021).
  • Skvortsova, I. Cancer Stem Cells: What Do We Know about Them? Cells, 10(6):1528. (2021).
  • Jöhrer, K. & Ҫiҫek, S. S. Multiple Myeloma Inhibitory Activity of Plant Natural Products. Cancers (Basel), 13(11):2678. (2021).
  • Kripnerová, M., Parmar, H. S., Šána, J., Kopková, A., Radová, L., Sopper, S., Biernacki, K., Jedlička, J., Kohoutová, M., Kuncová, J., Peychl, J., Rudolf, E., Červinka, M., Houdek, Z., Dvořák, P., Houfková, K., Pešta, M., Tůma, Z., Dolejšová, M., Tichánek, F., Babuška, V., Leba, M., Slabý, O. & Hatina, J. Complex Interplay of Genes Underlies Invasiveness in Fibrosarcoma Progression Model. J Clin Med, 10(11):2297. (2021).
  • Orfanoudaki, M., Hartmann, A., Alilou, M., Mehic, N., Kwiatkowski, M., Jöhrer, K., Nguyen Ngoc, H., Hensel, A., Greil, R. & Ganzera, M. Cytotoxic Compounds of Two Demosponges (Aplysina aerophoba and Spongia sp.) from the Aegean Sea. Biomolecules, 11(5):723. (2021).
  • Ploner, C., Rauchenwald, T., Connolly, C. E., Joehrer, K., Rainer, J., Seifarth, C., Hermann, M., Nagl, M., Lobenwein, S., Wilflingseder, D., Cappellano, G., Morandi, E. M. & Pierer, G. Oxidant therapy improves adipogenic differentiation of adipose-derived stem cells in human wound healing. Stem Cell Res Ther., 12(1):280. (2021).
  • Aschenbrenner, B., Negro, G., Savic, D., Sorokin, M., Buzdin, A., Ganswindt, U., Cemazar, M., Sersa, G., Skvortsov, S. & Skvortsova, I. Simvastatin is effective in killing the radioresistant breast carcinoma cells. Radiol Oncol., 55(3):305-316. (2021).
  • Senatore, E., Chiuso, F., Rinaldi, L., Intartaglia, D., Delle Donne, R., Pedone, E., Catalanotti, B., Pirone, L., Fiorillo, B., Moraca, F., Giamundo, G., Scala, G., Raffeiner, A., Torres-Quesada, O., Stefan, E., Kwiatkowski, M., van Pijkeren, A., Morleo, M., Franco, B., Garbi, C., Conte, I. & Feliciello, A. The TBC1D31/praja2 complex controls primary ciliogenesis through PKA-directed OFD1 ubiquitylation. EMBO J., 40(10):e106503. (2021).
  • Fleischmann, J., Feichtner, A., DeFalco, L., Kugler, V., Schwaighofer, S., Huber, R. G. & Stefan, E. Allosteric Kinase Inhibitors Reshape MEK1 Kinase Activity Conformations in Cells and In Silico. Biomolecules, 11(4):518. (2021).
  • Pournejati, R., Gust, R., Sagasser, J., Kircher, B., Jöhrer, K., Ghanbari, M. M. & Karbalaei-Heidari, H. R. In vitro evaluation of cytotoxic effects of di (2-ethylhexyl) phthalate (DEHP) produced by Bacillus velezensis strain RP137 isolated from Persian Gulf. Toxicol In Vitro, 73:105148. (2021).
  • Ҫiҫek, S. S., Willer, J., Preziuso, F., Sönnichsen, F., Greil, R., Girreser, U., Zidorn, C. & Jöhrer, K. Cytotoxic constituents and a new hydroxycinnamic acid derivative from Leontodon saxatilis (Asteraceae, Cichorieae). RSC Adv., 11(18):10489-10496. (2021).
  • Speckbacher, V., Zeilinger, S., Zimmermann, S., Mayhew, C. A., Wiesenhofer, H. & Ruzsanyi, V. Monitoring the volatile language of fungi using gas chromatography-ion mobility spectrometry. Anal Bioanal Chem., 413(11):3055-3067. (2021).
  • Ingruber, J., Savic, D., Steinbichler, T. B., Sprung, S., Fleischer, F., Glueckert, R., Schweigl, G., Skvortsova, I. I., Riechelmann, H. & Dudás, J. KLF4, Slug and EMT in Head and Neck Squamous Cell Carcinoma. Cells, 10(3):539. (2021).
  • Schoepf, A. M., Salcher, S., Obexer, P. & Gust, R. Tackling resistance in chronic myeloid leukemia: Novel cell death modulators with improved efficacy. Eur J Med Chem., 216:113285. (2021).
  • Buzdin, A., Skvortsova, I. I., Li, X. & Wang, Y. Editorial: Next Generation Sequencing Based Diagnostic Approaches in Clinical Oncology. Front Oncol., 10:635555. (2021).
  • Wolf, D. & Pircher, A. Vaccination influenz(a)ing cancer-specific survival. Int J Cancer, 148(8):1806-1807. (2021).
  • Lindner, A. K., Schachtner, G., Tulchiner, G., Thurnher, M., Untergasser, G., Obrist, P., Pipp, I., Steinkohl, F., Horninger, W., Culig, Z. & Pichler, R. Lynch Syndrome: Its Impact on Urothelial Carcinoma. Int J Mol Sci., 22(2):531. (2021).

2020

  • Ratiu, I. A., Ligor, T., Bocos-Bintintan, V., Mayhew, C. A. & Buszewski, B. Volatile Organic Compounds in Exhaled Breath as Fingerprints of Lung Cancer, Asthma and COPD. J Clin Med., 10(1):32. (2020).
  • Pournejati, R., Gust, R., Kircher, B. & Karbalaei-Heidari, H.R. Microindoline 581, an Indole Derivative from Microbacterium Sp. RP581 as A Novel Selective Antineoplastic Agent to Combat Hepatic Cancer Cells: Production, Optimization and Structural Elucidation. Iran J Pharm Res., 19(4):290-305. (2020).
  • Steiner, N., Jöhrer, K., Plewan, S., Brunner-Véber, A., Göbel, G., Nachbaur, D., Wolf, D., Gunsilius, E. & Untergasser, G. The FMS like Tyrosine Kinase 3 (FLT3) Is Overexpressed in a Subgroup of Multiple Myeloma Patients with Inferior Prognosis. Cancers (Basel), 12(9):2341. (2020).
  • Nagl, L., Horvath, L., Pircher, A. & Wolf, D. Tumor Endothelial Cells (TECs) as Potential Immune Directors of the Tumor Microenvironment – New Findings and Future Perspectives. Front Cell Dev Biol., 8:766. (2020).
  • Baecker, D., Kapp, T., Schumacher, P., Gust, R. & Kircher, B. Cell death-inducing properties of selected dendrimers against different breast cancer and leukemia cell lines. Arch Pharm (Weinheim), 353(11):e2000209. (2020).
  • Strashilov, S. A., Yordanov, A. D., Vasileva-Slaveva, M. B. & Konsoulova, A. A. Re-excision within a radius of 2 cm in patients with melanoma of the skin – sufficient for local oncological radicalness. Arch Med Sci., 18(3):690-695. (2020).
  • Steinbichler, T. B., Dudas, J., Ingruber, J., Glueckert, R., Sprung, S., Fleischer, F., Cidlinsky, N., Dejaco, D., Kofler, B., Giotakis, A. I., Skvortsova, I. I. & Riechelmann, H. Slug Is A Surrogate Marker of Epithelial to Mesenchymal Transition (EMT) in Head and Neck Cancer. J Clin Med., 9(7):2061. (2020).
  • Baecker, D., Ma, B. N., Sagasser, J., Schultz, L., Hörschläger, C., Weinreich, M., Steiner, L., Kircher, B. & Gust, R. Amide and ester derivatives of chlorido[4-carboxy-1,2-disalicylideneaminobenzene]iron(iii) as necroptosis and ferroptosis inducers. Dalton Trans., 49(20):6842-6853. (2020).
  • Skvortsova, I. I. & Span, P. N. Editorial: Advances in Biological Understanding of Tumor Radiation Resistance. Front Oncol., 10:754. (2020).
  • Schoepf, A. M., Salcher, S., Hohn, V., Veider, F., Obexer, P. & Gust, R. Synthesis and Characterization of Telmisartan-Derived Cell Death Modulators to Circumvent Imatinib Resistance in Chronic Myeloid Leukemia. ChemMedChem., 15(12):1067-1077. (2020).
  • Mildner, F., Sopper, S., Amann, A., Pircher, A., Pall, G., Köck, S., Naismith, E., Wolf, D. & Gamerith, G. Systematic review: Soluble immunological biomarkers in advanced non-small-cell lung cancer (NSCLC). Crit Rev Oncol Hematol., 153:102948. (2020).
  • Schoepf, A. M., Salcher, S., Obexer, P., Gust, R. Identification and development of non-cytotoxic cell death modulators: Impact of sartans and derivatives on PPARγ activation and on growth of imatinib-resistant chronic myelogenous leukemia cells. Eur J Med Chem., 195:112258. (2020).
  • Arnold, C. R., Mangesius, J., Skvortsova, I. I. & Ganswindt, U. The Role of Cancer Stem Cells in Radiation Resistance. Front Oncol., 10:164. (2020).
  • Negro, G., Aschenbrenner, B., Brezar, S. K., Cemazar, M., Coer, A., Gasljevic, G., Savic, D., Sorokin, M., Buzdin, A., Callari, M., Kvitsaridze, I., Jewett, A., Vasileva-Slaveva, M., Ganswindt, U., Skvortsova, I. & Skvortsov, S. Molecular heterogeneity in breast carcinoma cells with increased invasive capacities. Radiol Oncol., 54(1):103-118. (2020).
  • Jöhrer, K., Stuppner, H., Greil, R. & Çiçek, S. S. Structure-Guided Identification of Black Cohosh (Actaea racemosa) Triterpenoids with In Vitro Activity against Multiple Myeloma. Molecules, 11;25(4):766. (2020).
  • Neuwirt, H., Bouchal, J., Kharaishvili, G., Ploner, C., Jöhrer, K., Pitterl, F., Weber, A., Klocker, H. & Eder, I. E. Cancer-associated fibroblasts promote prostate tumor growth and progression through upregulation of cholesterol and steroid biosynthesis. Cell Commun Signal., 18(1):11. (2020).
  • Borjan, B., Kern, J., Steiner, N., Gunsilius, E., Wolf, D. & Untergasser, G. Spliced XBP1 Levels Determine Sensitivity of Multiple Myeloma Cells to Proteasome Inhibitor Bortezomib Independent of the Unfolded Protein Response Mediator GRP78. Front Oncol., 9:1530. (2020).

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