Established in 2006, the Laboratory for Experimental and Translational Research on Radiation Oncology (EXTRO-Lab) is an integral research and training component of the Department of Therapeutic Radiology and Oncology at Medical University of Innsbruck (Director Prof. Dr. Ute Ganswindt). The team of Dr. Ira-Ida Skvortsova is interested in basic research that has direct clinical applicability. The research program is dedicated to understanding the molecular mechanisms underlying the sensitivity of cancer cells to radiation therapy. Currently, cancer researchers worldwide support the carcinoma stem cell (CSC) hypothesis. Thus, it is believed that CSCs possess specific molecular properties associated with tumor heterogeneity, therapy resistance and inclination for metastatic spread. Therefore, EXTRO-Lab members work on the elucidation of the molecular patterns of CSCs that could help to develop novel biomarkers and therapeutic targets to predict and/or combat the most aggressive and treatment-resistant malignancies.