Publikationsliste
Functional analyses of Src-like adaptor (SLA), a glucocorticoid-regulated gene in acute lymphoblastic leukemia.
Mansha M, Carlet M, Ploner C, Gruber G, Wasim M, Wiegers GJ, Rainer J, Geley S, Kofler R.
Leukemia Research 1 Apr 2010; 34(4)529-34.
Repression of the BH3-only molecule PMAIP1/Noxa impairs glucocorticoid sensitivity of acute lymphoblastic leukemia cells
Ploner C, Rainer J, Lobenwein S, Geley S, Kofler R.
Apoptosis 1 Jun 2009; 14(6)821-8.
Levels of glucocorticoid receptor and its ligand determine sensitivity and kinetics of glucocorticoid-induced leukemia apoptosis.
Gruber G, Carlet M, Türtscher E, Meister B, Irving JA, Ploner C, Kofler R.
Leukemia 1 Apr 2009; 23(4)820-3.
The BCL2 rheostat in glucocorticoid-induced apoptosis of acute lymphoblastic leukemia.
Ploner C, Rainer J, Niederegger H, Eduardoff M, Villunger A, Geley S, Kofler R.
Epub 2007 Nov 29. 1 Feb 2008; 22(2)7-370.
Identification, tissue expression, and glucocorticoid responsiveness of alternative first exons of the human glucocorticoid receptor.
Presul E, Schmidt S, Kofler R, Helmberg A.
J Mol Endocrinol. 1 Feb 2007; 38(1-2)79-90.
Glucocorticoid resistance in two key models of acute lymphoblastic leukemia occurs at the level of the glucocorticoid receptor.
Schmidt S, Irving JA, Minto L, Matheson E, Nicholson L, Ploner A, Parson W, Kofler A, Amort M, Erdel M, Hall A, Kofler R.
FASEB J. 1 Dec 2006; 20(14)2600-2. Epub 2006 Oct 31.
A retroviral expression system based on tetracycline-regulated tricistronic transactivator/repressor vectors for functional analyses of antiproliferative and toxic genes.
Ausserlechner MJ, Obexer P, Deutschmann A, Geiger K, Kofler R.
Mol Cancer Ther. 1 Aug 2006; 5(8)1927-34.
Suppression of KCMF1 by constitutive high CD99 expression is involved in the migratory ability of Ewing's sarcoma cells.
Kreppel M, Aryee DN, Schaefer KL, Amann G, Kofler R, Poremba C, Kovar H.
Oncogene. 4 May 2006; 25(19)2795-800.
Oxindole alkaloids from Uncaria tomentosa induce apoptosis in proliferating, G0/G1-arrested and bcl-2-expressing acute lymphoblastic leukaemia cells.
Bacher N, Tiefenthaler M, Sturm S, Stuppner H, Ausserlechner MJ, Kofler R, Konwalinka G.
Br J Haematol. 1 Mar 2006; 132(5)615-22.
Identification of glucocorticoid-response genes in children with acute lymphoblastic leukemia.
Schmidt S, Rainer J, Riml S, Ploner C, Jesacher S, Achmuller C, Presul E, Skvortsov S, Crazzolara R, Fiegl M, Raivio T, Janne OA, Geley S, Meister B, Kofler R.
Blood. 1 Mar 2006; 107(5)2061-9. Epub 2005 Nov 17.
G1 arrest by p16INK4A uncouples growth from cell cycle progression in leukemia cells with deregulated cyclin E and c-Myc expression.
Ausserlechner MJ, Obexer P, Geley S, Kofler R.
Leukemia. 1 Jun 2005; 19(6)1051-7.
Cancer cell line identification by short tandem repeat profiling: power and limitations.
Parson W, Kirchebner R, Muhlmann R, Renner K, Kofler A, Schmidt S, Kofler R.
FASEB J. 1 Mar 2005; 19(3)434-6. Epub 2005 Jan 6.
Glucocorticoid-induced apoptosis and glucocorticoid resistance in acute lymphoblastic leukemia.
Ploner C, Schmidt S, Presul E, Renner K, Schrocksnadel K, Rainer J, Riml S, Kofler R.
J Steroid Biochem Mol Biol. 1 Feb 2005; 93(2-5)153-60. Epub 2005 Jan 26.
Glucocorticoid-induced apoptosis and glucocorticoid resistance: molecular mechanisms and clinical relevance.
Schmidt S, Rainer J, Ploner C, Presul E, Riml S, Kofler R.
Cell Death Differ. 1 Jul 2004; 11(Suppl 1)45-55.
Glucocorticoid receptor heterozygosity combined with lack of receptor auto-induction causes glucocorticoid resistance in Jurkat acute lymphoblastic leukemia cells.
Riml S, Schmidt S, Ausserlechner MJ, Geley S, Kofler R.
Cell Death Differ. 1 Jul 2004; 11(Suppl 1)65-72.
Cyclin D3 and c-MYC control glucocorticoid-induced cell cycle arrest but not apoptosis in lymphoblastic leukemia cells.
Ausserlechner MJ, Obexer P, Bock G, Geley S, Kofler R.
Cell Death Differ. 1 Feb 2004; 11(2)165-74.
A conceptual view on glucocorticoid-lnduced apoptosis, cell cycle arrest and glucocorticoid resistance in lymphoblastic leukemia.
Renner K, Ausserlechner MJ, Kofler R.
Curr Mol Med. 1 Dec 2003; 3(8)707-17.
Changes of mitochondrial respiration, mitochondrial content and cell size after induction of apoptosis in leukemia cells.
Renner K, Amberger A, Konwalinka G, Kofler R, Gnaiger E.
Biochim Biophys Acta. 23 Sep 2003; 1642(1-2)115-23.
Resistance to glucocorticoid-induced apoptosis in lymphoblastic leukemia.
Kofler R, Schmidt S, Kofler A, Ausserlechner MJ.
J Endocrinol. 1 Jul 2003; 178(1)19-27.
Enhanced MTT-reducing activity under growth inhibition by resveratrol in CEM-C7H2 lymphocytic leukemia cells.
Bernhard D, Schwaiger W, Crazzolara R, Tinhofer I, Kofler R, Csordas A.
Cancer Lett. 10 Jun 2003; 195(2)193-9.
Histone deacetylase inhibitors potently repress CXCR4 chemokine receptor expression and function in acute lymphoblastic leukaemia.
Crazzolara R, Johrer K, Johnstone RW, Greil R, Kofler R, Meister B, Bernhard D.
Br J Haematol. 1 Dec 2002; 119(4)965-9.
Regulation and function of the cytokine-inducible SH-2 domain proteins, CIS and SOCS3, in mammary epithelial cells.
Tonko-Geymayer S, Goupille O, Tonko M, Soratroi C, Yoshimura A, Streuli C, Ziemiecki A, Kofler R, Doppler W.
Mol Endocrinol. 1 Jul 2002; 16(7)1680-95.
Suberoylanilide hydroxamic acid (SAHA) overcomes multidrug resistance and induces cell death in P-glycoprotein-expressing cells.
Ruefli AA, Bernhard D, Tainton KM, Kofler R, Smyth MJ, Johnstone RW.
Int J Cancer. 10 May 2002; 99(2)292-8.
Mitochondrial function in glucocorticoid triggered T-ALL cells with transgenic bcl-2 expression.
Renner K, Kofler R, Gnaiger E.
Mol Biol Rep. 1 Jan 2002; 29(1-2)97-101.
Inhibition of histone deacetylase activity enhances Fas receptor-mediated apoptosis in leukemic lymphoblasts.
Bernhard D, Skvortsov S, Tinhofer I, Hubl H, Greil R, Csordas A, Kofler R.
Cell Death Differ. 1 Oct 2001; 8(10)1014-21.
The histone deacetylase inhibitor and chemotherapeutic agent suberoylanilide hydroxamic acid (SAHA) induces a cell-death pathway characterized by cleavage of Bid and production of reactive oxygen species.
Ruefli AA, Ausserlechner MJ, Bernhard D, Sutton VR, Tainton KM, Kofler R, Smyth MJ, Johnstone RW.
Proc Natl Acad Sci U S A. 11 Sep 2001; 98(19)10833-8. Epub 2001 Sep 4.
Increased lactate production follows loss of mitochondrial membrane potential during apoptosis of human leukaemia cells.
Tiefenthaler M, Amberger A, Bacher N, Hartmann BL, Margreiter R, Kofler R, Konwalinka G.
Br J Haematol. 2001 Sep;114(3):574-80. 1 Sep 2001; 117(3)574-80.
Mitochondrial membrane sensitivity to depolarization in acute myeloblastic leukemia is associated with spontaneous in vitro apoptosis, wild-type TP53, and vicinal thiol/disulfide status.
Pallis M, Grundy M, Turzanski J, Kofler R, Russell N.
Blood. 15 Jul 2001; 98(2)405-13.
The cell cycle inhibitor p16(INK4A) sensitizes lymphoblastic leukemia cells to apoptosis by physiologic glucocorticoid levels.
Ausserlechner MJ, Obexer P, Wiegers GJ, Hartmann BL, Geley S, Kofler R.
J Biol Chem. 15 Jun 2001; 276(24)10984-9.
Resveratrol, a tumor-suppressive compound from grapes, induces apoptosis via a novel mitochondrial pathway controlled by Bcl-2.
Tinhofer I, Bernhard D, Senfter M, Anether G, Loeffler M, Kroemer G, Kofler R, Csordas A, Greil R.
FASEB J. 1 Jun 2001; 15(9)1613-5.
Gene expression profiles of proliferating vs. G1/G0 arrested human leukemia cells suggest a mechanism for glucocorticoid-induced apoptosis.
Tonko M, Ausserlechner MJ, Bernhard D, Helmberg A, Kofler R.
FASEB J. 1 Mar 2001; 15(3)693-9.
The molecular basis of glucocorticoid-induced apoptosis of lymphoblastic leukemia cells.
Kofler R.
Histochem Cell Biol. 1 May 2000; 114(1)1-7. Review
