Publikationsliste
Pyruvate kinase isoenzyme M2 is a glycolytic sensor differentially regulating cell proliferation, cell size and apoptotic cell death dependent on glucose supply.
Spoden GA, Rostek U, Lechner S, Mitterberger M, Mazurek S, Zwerschke W.
Exp Cell Res. 27 Jun 2009; (). [Epub ahead of print]
The SUMO-E3 ligase PIAS3 targets pyruvate kinase M2.
Spoden GA, Morandell D, Ehehalt D, Fiedler M, Jansen-Dürr P, Hermann M, Zwerschke W.
J Cell Biochem 10 Feb 2009; 107(2)293-302.
Human papillomavirus type 45 E7 is a transforming protein inducing retinoblastoma protein degradation and anchorage-independent cell cycle progression.
Morandell, D., Rostek, U., Bouvard, V., Campo-Fernández, B., Fiedler, M. Jansen-Dürr, P., and W. Zwerschke.
Virology 15 Sep 2008; 379(1)20-9.
Isotype-specific inhibitors of the glycolytic key regulator pyruvate kinase subtype M2 moderately decelerate tumor cell proliferation.
Spoden GA, Mazurek S, Morandell D, Bacher N, Ausserlechner MJ, Jansen-Dürr P, Eigenbrodt E, Zwerschke W.
Int J Cancer 18 Apr 2008; 123(2)312-321. [Epub ahead of print]
High-risk human papillomavirus E7 oncoprotein detection in cervical squamous cell carcinoma.
Ressler S, Scheiden R, Dreier K, Laich A, Müller-Holzner E, Pircher H, Morandell D, Stein I, Viertler HP, Santer FR, Widschwendter A, Even J, Jansen-Dürr P, Capesius C, Zwerschke W.
Clin Cancer Res 1 Dec 2007; 13()7067-72.
High-risk HPV E7 oncoprotein expression in cervical squamous cell carcinoma.
Ressler, S., Scheiden, R., Dreier, K., Laich, A., Müller-Holzner, E., Pircher, H., Morandell, D., Stein, I., Viertler, H.P., Santer, F.R., Widschwendter, A., Even, J., Jansen-Dürr, P., Capesius, C. and W. Zwerschke
Clin Can Res. 1 Jan 2007; (13)7067-7072.
The human papillomavirus type 16 E7 oncoprotein inhibits
apoptosis induced by nuclear insulin-like growth factor binding
protein-3 by inducing its ubiquitin/proteasome-dependent degradation.
Santer, F., Moser, B., Spoden, G.A., Jansen-Dürr, P., and W. Zwerschke.
Carcinogenesis 1 Jan 2007; 28()2511-2520.
Identification of the FHL2 transcriptional coactivator as a new functional target of the E7 oncoprotein of human papillomavirus type 16.
Campo-Fernandez B, Morandell D, Santer FR, Zwerschke W, Jansen-Durr P.
J Virol. 1 Jan 2007; 81(2)1027-32. Epub 2006 Nov 8.
Purification and characterisation of the E7 oncoproteins of the high-risk human papillomavirus types 16 and 18.
Fiedler M, Campo-Fernandez B, Laich A, Moser B, Stockl P, Jansen-Durr P, Zwerschke W.
J Virol Methods. 1 Jun 2006; 134(1-2)30-5. Epub 2005 Dec 27.
Nuclear insulin-like growth factor binding protein-3 induces apoptosis and is targeted to ubiquitin/proteasome-dependent proteolysis.
Santer FR, Bacher N, Moser B, Morandell D, Ressler S, Firth SM, Spoden GA, Sergi C, Baxter RC, Jansen-Durr P, Zwerschke W.
Cancer Res. 15 Mar 2006; 66(6)3024-33.
Expression of the high-risk human papillomavirus type 18 and 45 E7 oncoproteins in cervical carcinoma biopsies.
Fiedler M, Ressler S, Campo-Fernandez B, Laich A, Jansen L, Widschwendter A, Viertler HP, Bacher N, Morandell D, Muller-Holzner E, Durst M, Jansen-Durr P, Zwerschke W.
J Gen Virol. 1 Dec 2005; 86(Pt 12)3235-41.
Apoptosis resistance of senescent human fibroblasts is correlated with the absence of nuclear IGFBP-3.
Hampel B, Wagner M, Teis D, Zwerschke W, Huber LA, Jansen-Durr P.
Aging Cell. 1 Dec 2005; 4(6)325-30.
High level HPV-16 E7 oncoprotein expression correlates with reduced pRb-levels in cervical biopsies.
Fiedler M, Muller-Holzner E, Viertler HP, Widschwendter A, Laich A, Pfister G, Spoden GA, Jansen-Durr P, Zwerschke W.
FASEB J. 1 Jun 2004; 18(10)1120-2. pub 2004 May 20.
Metabolic analysis of senescent human fibroblasts reveals a role for AMP in cellular senescence.
Zwerschke W, Mazurek S, Stockl P, Hutter E, Eigenbrodt E, Jansen-Durr P.
Biochem J. 1 Dec 2003; 376(Pt 2)403-11.
Senescence-associated cell death of human endothelial cells: the role of oxidative stress.
Unterluggauer H, Hampel B, Zwerschke W, Jansen-Durr P.
Exp Gerontol. 1 Oct 2003; 38(10)1149-60.
Metabolic cooperation between different oncogenes during cell transformation: interaction between activated ras and HPV-16 E7.
Mazurek S, Zwerschke W, Jansen-Durr P, Eigenbrodt E.
Oncogene. 18 Oct 2001; 20(47)6891-8.
Replicative senescence of human endothelial cells in vitro involves G1 arrest, polyploidization and senescence-associated apoptosis.
Wagner M, Hampel B, Bernhard D, Hala M, Zwerschke W, Jansen-Durr P.
Exp Gerontol. 1 Aug 2001; 36(8)1327-47.
Effects of the human papilloma virus HPV-16 E7 oncoprotein on glycolysis and glutaminolysis: role of pyruvate kinase type M2 and the glycolytic-enzyme complex.
Mazurek S, Zwerschke W, Jansen-Durr P, Eigenbrodt E.
Biochem J. 15 May 2001; 356(Pt 1)247-56.
Induction of apoptosis in cervical carcinoma cells by peptide aptamers that bind to the HPV-16 E7 oncoprotein.
Nauenburg S, Zwerschke W, Jansen-Durr P.
FASEB J. 1 Mar 2001; 15(3)592-4. Epub 2001 Jan 19.
Human papillomavirus type 16 E7 oncoprotein binds and inactivates growth-inhibitory insulin-like growth factor binding protein 3
Mannhardt B, Weinzimer SA, Wagner M, Fiedler M, Cohen P, Jansen-Durr P, Zwerschke W.
Mol Cell Biol. 1 Sep 2000; 20(17)6483-95.
Peptide aptamers as isotype-specific inhibitors of the metabolic keyregulator pyruvate kinase subtype M2.
Spoden, G. A., Mazurek, S., Morandell, D., Bacher, N., Ausserlechner, M., Jansen-Dürr, P., Eigenbrodt E., and W. Zwerschke.
Int J Cancer. In press. ; ().
Insulin-like Growth Factor-binding Protein-3 in Osteosarcomas and Normal Bone Tissues.
Ressler S, Radhi J, Aigner T, Loo C, Zwerschke W, Sergi C.
Anticancer Res. ; 29(7)2579-87.