Publications
2006
Wandke,C. and S.Geley. 2006. Generation and characterization of an hKid-specific monoclonal antibody. Hybridoma (Larchmt. ) 25:41-43.Stadlmann,S., K.Renner, J.Pollheimer, P.L.Moser, A.G.Zeimet, F.A.Offner, and E.Gnaiger. 2006. Preserved Coupling of Oxidative Phosphorylation But Decreased Mitochondrial Respiratory Capacity in IL-1beta-Treated Human Peritoneal Mesothelial Cells. Cell Biochem. Biophys. 44:179-186.
Bacher,N., M.Tiefenthaler, S.Sturm, H.Stuppner, M.J.Ausserlechner, R.Kofler, and G.Konwalinka. 2006. Oxinddole alkaloids from Uncaria tomentosa induce apoptosis in proliferating, G0/G1-arrested and bcl-2 expressing acute lymphoblastic leukaemia cells. Br. J. Haematol. 132:615-622.
Schmidt,S., J.Rainer, S.Riml, C.Ploner, S.Jesacher, C.Achmüller, E.Presul, S.Skvortsov, R.Crazzolara, M.Fiegl, T.Raivio, O.A.Jänne, S.Geley, B.Meister, and R.Kofler. 2006. Identification of glucocorticoid response genes in children with acute lymphoblastic leukemia. Blood 107:2061-2069.
2005
Tzankov,A., A.Zimpfer, P.Went, R.Maurer, S.A.Pileri, S.Geley, and S.Dirnhofer. 2005. Aberrant expression of cell cycle regulators in Hodgkin and Reed-Sternberg cells of classical Hodgkin's lymphoma. Mod. Pathol. 18:90-96.Ploner,C., S.Schmidt, E.Presul, K.Renner, K.Schröcksnadel, J.Rainer, S.Riml, and R.Kofler. 2005. Glucocorticoid-induced apoptosis and glucocorticoid resistance in acute lymphoblastic leukemia. J. Steroid Biochem. Mol. Biol. 93:153-160.
Parson,W., R.Kirchebner, R.Mühlmann, K.Renner, A.Kofler, S.Schmidt, and R.Kofler. 2005. Leukemia cell line identification by short tandem repeat profiling: power and limitations. FASEB J. 19:434-436.
Ausserlechner,M.J., P.Obexer, S.Geley, and R.Kofler. 2005. G1 arrest by P16INK4A uncouples growth from cell cycle progression inleukemia cells with deregulated cyclin E and c-myc expression. Leukemia 19:1051-1057.
2004
Tsurumi,C., S.Hoffmann, S.Geley, R.Graeser, and Z.Polanski. 2004. The spindle assembly checkpoint is not essential for CSF arrest of mouse oocytes. J. Cell Biol. 167:1037-1050.Schmidt,S., J.Rainer, C.Ploner, E.Presul, S.Riml, and R.Kofler. 2004. Glucocorticoid-induced apoptosis and glucocorticoid resistance: Molecular mechanisms and clinical relevance. Cell Death Differ. 11 Suppl 1:S45-S55.
Riml,S., S.Schmidt, M.J.Ausserlechner, S.Geley, and R.Kofler. 2004. Glucocorticoid receptor heterozygosity combined with lack of receptor auto-induction causes glucocorticoid resistance in Jurkat acute lymphoblastic leukemia cells. Cell Death Differ. 11 Suppl 1:S65-S72.
Geley,S. and C.Muller. 2004. RNAi: ancient mechanism with a promising future. Exp. Gerontol. 39:985-998.
Ausserlechner,M.J., P.Obexer, G.Böck, S.Geley, and R.Kofler. 2004. Cyclin D3 and c-myc control glucocorticoid-induced cell cycle arrest but not apoptosis in lymphoblastic leukemia cells. Cell Death Differ. 11:165-174.
Hutter,E., K.Renner, G.Pfister, P.Stockl, P.Jansen-Durr, and E.Gnaiger. 2004. Senescence-associated changes in respiration and oxidative phosphorylation in primary human fibroblasts. Biochem. J. 380:919-928.
2003
Larcher,C., D.Bernhard, E.Schaadt, B.Adler, M.J.Ausserlechner, M.Mitterer, and H.P.Huemer. 2003. Functional analysis of the mutated Epstein-Barr virus oncoprotein LMP1(69del): implications for a new role of naturally occurring LMP1 variants. Haematologica 88:1324-1335.Kofler,R., S.Schmidt, A.Kofler, and M.J.Ausserlechner. 2003. Resistance to glucocorticoid-induced apoptosis in lymphoblastic leukemia. J. Endocrinol. 178:19-27.
Bernhard,D., W.Schwaiger, R.Crazzolara, I.Tinhofer, R.Kofler, and A.Csordas. 2003. Enhanced MTT-reducing activity under growth inhibition by resveratrol in CEM-C7H2 lymphocytic leukemia cells. Cancer Lett. 195:193-199.
Villunger,A., E.M.Michalak, L.Coultas, F.Mullauer, G.Bock, M.J.Ausserlechner, J.M.Adams, and A.Strasser. 2003. p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa. Science 302:1036-1038.
Tzankov,A., A.Zimpfer, A.Lugli, J.Krugmann, P.Went, P.Schraml, R.Maurer, S.Ascani, S.Pileri, S.Geley, and S.Dirnhofer. 2003. High-throughput tissue microarray analysis of G1-cyclin alterations in classical Hodgkin's lymphoma indicates overexpression of cyclin E1. J. Pathol. 199:201-207.
Renner,K., M.J.Ausserlechner, and R.Kofler. 2003. A conceptual view on glucocorticoid-induced apoptosis, cell cycle arrest and glucocorticoid resistance in lymphoblastic leukemia. Curr. Mol. Med. 3:707-717.
2002
Tonko-Geymayer,S., O.Goupille, M.Tonko, C.Soratroi, A.Yoshimura, C.Streuli, A.Ziemiecki, R.Kofler, and W.Doppler. 2002. Regulation and function of the cytokine inducible SH-2 domain proteins cis and socs3 in mammary epithelial cells. Mol. Endocrinol. 16:1680-1695.Ruefli,A.A., D.Bernhard, K.Tainton, R.Kofler, M.J.Smyth, and R.W.Johnstone. 2002. Suberoylanilide hydroxamic acid (SAHA) overcomes multidrug resistance and induces cell death in P-gp expressing cells. Int. J. Cancer 99:292-298.
Crazzolara,R., K.Jöhrer, R.W.Johnstone, R.Greil, R.Kofler, B.Meister, and D.Bernhard. 2002. Histone deacetylase inhibitors potently repress CXCR4 chemokine receptor expression and function in acute lymphoblastic leukemia. Br. J. Haematol. 119:965-969.
2001
Tonko,M., M.J.Ausserlechner, D.Bernhard, A.Helmberg, and R.Kofler. 2001. Gene expression profiles of proliferating versus G1/G0 arrested human leukemia cells suggest a mechanism for glucocorticoid-induced apoptosis. FASEB J. 15:693-699.Tinhofer,I., D.Bernhard, M.Senfter, G.Anether, M.Loeffler, G.Kroemer, R.Kofler, A.Csordas, and R.Greil. 2001. Resveratrol, a tumor-suppressive compound from grapes, induces apoptosis via a novel mitochondrial pathway controlled by Bcl-2. FASEB J. 9:1613-1615.
Tiefenthaler,M., A.Amberger, N.Bacher, B.L.Hartmann, R.Margreiter, R.Kofler, and G.Konwalinka. 2001. Increased lactate production follows loss of mitochondrial membrane potential during apoptosis of human leukaemia cells. Br. J. Haematol. 114:574-580.
Ruefli,A.A., M.J.Ausserlechner, D.Bernhard, V.R.Sutton, K.M.Tainton, R.Kofler, M.J.Smyth, and R.W.Johnstone. 2001. The histone deacetylase inhibitor and chemotherapeutic agent suberoylanilide hydroxamic acid (SAHA) induces a cell-death pathway characterized by cleavage of Bid and production of reactive oxygen species. Proc. Natl. Acad. Sci. U. S. A. 98:10833-10838.
Pallis,M., M.Grundy, J.Turzanski, R.Kofler, and N.Russel. 2001. Mitochondrial membrane sensitivity to depolarization in acute myeloblastic leukaemia is associated with spontaneous in vitro apoptosis, wild-type TP53 and vicinal thiol/disulphide status. Blood 98:405-413.
Obexer,P., U.Certa, R.Kofler, and A.Helmberg. 2001. Expression profiling of glucocorticoid-treated T-ALL cell lines: rapid repression of multiple genes involved in RNA-, protein- and nucleotide synthesis. Oncogene 20:4324-4336.
Helmberg,A. 2001. DNA-microarrays: novel techniques to study aging and guide gerontologic medicine. Exp. Gerontol. 36:1189-1198.
Bernhard,D., S.Skvortsov, I.Tinhofer, H.Hübl, R.Greil, A.Csordas, and R.Kofler. 2001. Inhibition of histone deacetylase activity enhances fas-induced apoptosis in leukemic lymphoblasts. Cell Death Differ. 8:1014-1021.
Wagner,M., B.Hampel, D.Bernhard, M.Hala, W.Zwerschke, and P.Jansen-Durr. 2001. Replicative senescence of human endothelial cells in vitro involves G1 arrest, polyploidization and senescence-associated apoptosis. Exp. Gerontol. 36:1327-1347.
Ausserlechner,M.J., P.Obexer, G.J.Wiegers, B.L.Hartmann, S.Geley, and R.Kofler. 2001. The cell cycle inhibitor p16/INK4A sensitizes lymphoblastic leukemia cells to apoptosis by physiologic glucocorticoid levels. J. Biol. Chem. 276:10984-10989.
2000
Kuhr,T., O.Bechter, S.Dirnhofer, S.Geley, A.Gachter, G.Pall, M.Url, H.Dietrich, P.Oberaigner, G.Klima, W.Eisterer, W.Hilbe, P.Lukas, and J.Thaler. 2000. Transplantation of IL-2-transduced murine bone marrow is associated with dose-dependent toxicity. Exp. Hematol. 28:895-906.Bernhard,D., I.Tinhofer, M.Tonko, H.Hübl, M.J.Ausserlechner, R.Greil, R.Kofler, and A.Csordas. 2000. Resveratrol causes arrest in the S-phase prior to fas-independent apoptosis in CEM-C7H2 acute leukemia cells. Cell Death Differ. 7:834-842.
Kofler,R. 2000. The molecular basis of glucocorticoid-induced apoptosis of lymphoblastic leukemia cells. Histochem. Cell Biol. 114:1-7.