Publikationen
2012
Goebel,G., R.Berger, A.M.Strasak, D.Egle,
E.Muller-Holzner, S.Schmidt, J.Rainer, E.Presul, W.Parson, S.Lang, A.Jones,
M.Widschwendter, and H.Fiegl. 2012. Elevated mRNA expression of CHAC1 splicing
variants is associated with poor outcome for breast and ovarian cancer
patients. Br.J.Cancer 106:189-198.
Mansha,M., M.Wasim, A.Kofler, and C.Ploner.
2012. Expression and glucocorticoid-regulation of "Bam", a novel
BH3-only transcript in acute lymphoblastic leukemia. Mol.Biol.Rep. in
press.
Rainer,J., J.Lelong, D.Bindreither,
C.Mantinger, C.Ploner, S.Geley, and R.Kofler. 2012. Research resource:
transcriptional response to glucocorticoids in childhood acute lymphoblastic
leukemia. Mol.Endocrinol. 26:178-193.
2011
Barisic,M. and S.Geley. 2011. Spindly
switch controls anaphase: spindly and RZZ functions in chromosome attachment
and mitotic checkpoint control. Cell Cycle 10:449-456.
Eberhart,K., J.Rainer, D.Bindreither,
I.Ritter, E.Gnaiger, R.Kofler, P.J.Oefner, and K.Renner. 2011.
Glucocorticoid-induced alterations in mitochondrial membrane properties and
respiration in childhood acute lymphoblastic leukemia. Biochim.Biophys.Acta
1807:719-725.
Fuka,G., M.Kauer, R.Kofler, O.A.Haas, and
R.Panzer-Grumayer. 2011. The leukemia-specific fusion gene ETV6/RUNX1 perturbs
distinct key biological functions primarily by gene repression. PLoS ONE
6:e26348.
Grespi,F., E.Ottina, N.Yannoutsos, S.Geley,
and A.Villunger. 2011. Generation and evaluation of an IPTG-regulated version
of Vav-gene promoter for mouse transgenesis. PLoS ONE 6:e18051.
Hausmann,M., K.Leucht, C.Ploner,
S.Kiessling, A.Villunger, H.Becker, C.Hofmann, W.Falk, M.Krebs, S.Kellermeier,
M.Fried, J.Scholmerich, F.Obermeier, and G.Rogler. 2011. BCL-2 Modifying Factor
(BMF) Is a Central Regulator of Anoikis in Human Intestinal Epithelial Cells. J.Biol.Chem.
286:26533-26540.
Kuster,L., R.Grausenburger, G.Fuka,
U.Kaindl, G.Krapf, A.Inthal, G.Mann, M.Kauer, J.Rainer, R.Kofler, A.Hall,
M.Metzler, L.H.Meyer, C.Meyer, J.Harbott, R.Marschalek, S.Strehl, O.A.Haas, and
R.Panzer-Grumayer. 2011. ETV6/RUNX1-positive relapses evolve from an ancestral
clone and frequently acquire deletions of genes implicated in glucocorticoid
signaling. Blood 117:2658-2667.
Mikolcevic,P., R.Sigl, V.Rauch, M.W.Hess,
K.Pfaller, M.Barisic, L.J.Pelliniemi, M.Boesl, and S.Geley. 2011. CDK16/PCTAIRE
kinase 1 is activated by Cyclin Y and is essential for spermatogenesis. Mol.Cell
Biol. in press.
Oppl,B., A.Kofler, S.Schwarz, J.Rainer, and
R.Kofler. 2011. Establishing a sensitive and specific assay for determination
of glucocorticoid bioactivity. Wien.Klin.Wochenschr. 123:222-229.
Prokudin,I., T.Stasyk, J.Rainer, G.K.Bonn,
R.Kofler, and L.A.Huber. 2011. Comprehensive proteomic and transcriptomic
characterization of hepatic expression signatures affected in p14 liver
conditional knockout mice. Proteomics. 11:469-480.
Sanchez-Cabo,F., J.Rainer, A.Dopazo,
Z.Trajanoski, and H.Hackl. 2011. Insights into global mechanisms and disease by
gene expression profiling. In Bioinformatics for Omics Data. B.Mayer,
editor. Humana Press, New York. 269-298.
2010
Aryee,D.N., S.Niedan, M.Kauer,
R.Schwentner, I.M.nani-Baiti, J.Ban, K.Muehlbacher, M.Kreppel, R.L.Walker,
P.Meltzer, C.Poremba, R.Kofler, and H.Kovar. 2010. Hypoxia modulates EWS-FLI1
transcriptional signature and enhances the malignant properties of Ewing's
sarcoma cells in vitro. Cancer Res. 70:4015-4023.
Barisic,M., B.Sohm, P.Mikolcevic, C.Wandke,
V.Rauch, T.Ringer, M.Hess, G.Bonn, and S.Geley. 2010. Spindly/CCDC99 Is
Required for Efficient Chromosome Congression and Mitotic Checkpoint
Regulation. Mol.Biol.Cell 21:1968-1981.
Carlet,M., K.Janjetovic, J.Rainer,
S.Schmidt, R.Panzer-Grumayer, G.Mann, M.Prelog, B.Meister, C.Ploner, and
R.Kofler. 2010. Expression, regulation and function of
phosphofructo-kinase/fructose-biphosphatases (PFKFBs) in glucocorticoid-induced
apoptosis of acute lymphoblastic leukemia cells. BMC.Cancer 10:638.
Frenzel,A., V.Labi, W.Chmelewskij,
C.Ploner, S.Geley, H.Fiegl, A.Tzankov, and A.Villunger. 2010. Suppression of B
cell lymphomagenesis by the BH3-only proteins Bmf and Bad. Blood
115:995-1005.
Grespi,F., C.Soratroi, G.Krumschnabel,
B.Sohm, C.Ploner, S.Geley, L.Hengst, G.Hacker, and A.Villunger. 2010. BH3-only
protein Bmf mediates apoptosis upon inhibition of CAP-dependent protein
synthesis. Cell Death.Differ. 17:1672-1683.
Mansha,M., M.Carlet, C.Ploner, G.Gruber,
M.Wasim, G.J.Wiegers, J.Rainer, S.Geley, and R.Kofler. 2010. Functional
analyses of Src-like adaptor (SLA), a glucocorticoid-regulated gene in acute
lymphoblastic leukemia. Leuk.Res. 34:529-534.
Wasim,M., M.Mansha, M.Carlet, R.Greil,
C.Ploner, A.Trockenbacher, J.Rainer, and R.Kofler. 2010. PLZF/ZBTB16, a
glucocorticoid response gene in acute lymphoblastic leukemia, interferes with
glucocorticoid-induced apoptosis. J.Steroid Biochem.Mol.Biol. 120:218-227.
2009
Eberhart,K., K.Renner, I.Ritter,
M.Kastenberger, K.Singer, C.Hellerbrand, M.Kreutz, R.Kofler, and P.J.Oefner.
2009. Low doses of 2-deoxy-glucose sensitize acute lymphoblastic leukemia cells
to glucocorticoid-induced apoptosis. Leukemia 23:2167-2170.
Ecker,K., A.Lorenz, F.Wolf, C.Ploner,
G.Böck, T.Duncan, S.Geley, and A.Helmberg. 2009. A ras recruitment screen
identifies ZKSCAN4 as a glucocorticoid receptor-interacting protein. J.Mol.Endocrinol.
42:105-117.
Gruber,G., M.Carlet, E.Turtscher,
B.Meister, J.A.Irving, C.Ploner, and R.Kofler. 2009. Levels of glucocorticoid
receptor and its ligand determine sensitivity and kinetics of
glucocorticoid-induced leukemia apoptosis. Leukemia 23:820-823.
Kauer,M., J.Ban, R.Kofler, B.Walker, S.Davis,
P.Meltzer, and H.Kovar. 2009. A molecular function map of Ewing´s sarcoma. PLoS
ONE 4:e5415.
Obexer,P., J.Hagenbuchner, M.Rupp,
C.Salvador, M.Holzner, M.Deutsch, V.Porto, R.Kofler, T.Unterkirchner, and
M.J.Ausserlechner. 2009. p16INK4A sensitizes human leukemia cells to FAS- and
glucocorticoid-induced apoptosis via induction of BBC3/Puma and repression of
MCL1 and BCL2. J.Biol.Chem. 284:30933-30940.
Ploner,A., C.Ploner, M.Lukasser,
H.Niederegger, and A.Huttenhofer. 2009. Methodological obstacles in knocking
down small noncoding RNAs. RNA. 15:1797-1804.
Ploner,C., J.Rainer, S.Lobenwein, S.Geley,
and R.Kofler. 2009. Repression of the BH3-only molecule PMAIP1/Noxa impairs
glucocorticoid sensitivity of acute lymphoblastic leukemia cells. Apoptosis
14:821-828.
Rainer,J., C.Ploner, S.Jesacher, A.Ploner,
M.Eduardoff, M.Mansha, M.Wasim, R.Panzer-Grümayer, Z.Trajanoski, H.Niederegger,
and R.Kofler. 2009. Glucocorticoid regulated microRNAs and mirtrons in acute
lymphoblastic leukemia. Leukemia 23:746-752.
Sigl,R., C.Wandke, V.Rauch, J.Kirk, T.Hunt,
and S.Geley. 2009. Loss of the mammalian APC/C activator FZR1 shortens G1 and
lengthens S phase but has little effect on exit from mitosis. J.Cell Sci.
122:4208-4217.
Weber,A., Z.Kirejczyk, S.Potthoff,
C.Ploner, and G.Hacker. 2009. Endogenous Noxa Determines the Strong
Proapoptotic Synergism of the BH3-Mimetic ABT-737 with Chemotherapeutic Agents
in Human Melanoma Cells. Transl.Oncol. 2:73-83.
2008
Ploner,C., R.Kofler, and A.Villunger. 2008.
Noxa: at the tip of the balance between live and death. Oncogene 27
Suppl 1:S84-S92.
Ploner,C., J.Rainer, H.Niederegger,
M.Eduardoff, A.Villunger, S.Geley, and R.Kofler. 2008. The BCL2 rheostat in
glucocorticoid-induced apoptosis of acute lymphoblastic leukemia. Leukemia
22:370-377.
2007
Jurgeit,A., C.Berlato, P.Obrist, C.Ploner,
P.Massoner, J.Schmolzer, M.C.Haffner, H.Klocker, L.A.Huber, S.Geley, and
W.Doppler. 2007. Insulin-like growth factor binding protein (IGFBP)-5 enters
vesicular structures but not the nucleus. Traffic 8:1815-1828.
Presul,E., S.Schmidt, R.Kofler, and
A.Helmberg. 2007. Identification, tissue specific expression and glucocorticoid
responsiveness of alternative first exons of the human glucocorticoid receptor.
J.Mol.Endocrinol. 38:79-90.
Wolf,F., R.Sigl, and S.Geley. 2007. '...
The End of the Beginning': Cdk1 Thresholds and Exit from Mitosis. Cell Cycle
6:1408-1411.
2006
Ausserlechner,M.J., P.Obexer,
A.Deutschmann, K.Geiger, and R.Kofler. 2006. A retroviral expression system
based on tetracycline-regulated tricistronic transactivator/repressor vectors
for functional analyses of antiproliferative and toxic genes. Mol.Cancer
Ther. 5:1927-1934.
Bacher,N., M.Tiefenthaler, S.Sturm,
H.Stuppner, M.J.Ausserlechner, R.Kofler, and G.Konwalinka. 2006. Oxinddole
alkaloids from Uncaria tomentosa induce apoptosis in proliferating,
G0/G1-arrested and bcl-2 expressing acute lymphoblastic leukaemia cells. Br.J.Haematol.
132:615-622.
Kreppel,M., D.N.T.Aryee, K.L.Schaefer,
G.Amann, R.Kofler, C.Poremba, and H.Kovar. 2006. Suppression of KCMF1 by
constitutive high CD99 expression is involved in the migration ability of
Ewing´s sarcoma cells. Oncogene 25:2795-2800.
Schmidt,S., J.A.Irving, L.Minto, E.Matheson,
L.Nicholson, A.Ploner, W.Parson, A.Kofler, M.Amort, M.Erdel, A.Hall, and
R.Kofler. 2006. Glucocorticoid resistance in two key models of acute
lymphoblastic leukemia occurs at the level of the glucocorticoid receptor. FASEB
J. 20:2600-2602.
Schmidt,S., J.Rainer, S.Riml, C.Ploner,
S.Jesacher, C.Achmüller, E.Presul, S.Skvortsov, R.Crazzolara, M.Fiegl,
T.Raivio, O.A.Jänne, S.Geley, B.Meister, and R.Kofler. 2006. Identification of
glucocorticoid response genes in children with acute lymphoblastic leukemia. Blood
107:2061-2069.
Stadlmann,S., K.Renner, J.Pollheimer,
P.L.Moser, A.G.Zeimet, F.A.Offner, and E.Gnaiger. 2006. Preserved Coupling of
Oxidative Phosphorylation But Decreased Mitochondrial Respiratory Capacity in
IL-1beta-Treated Human Peritoneal Mesothelial Cells. Cell Biochem.Biophys.
44:179-186.
Stadlmann,S., J.Pollheimer, K.Renner,
A.G.Zeimet, F.A.Offner, and A.Amberger. 2006. Response of human peritoneal
mesothelial cells to inflammatory injury is regulated by interleukin-1beta and
tumor necrosis factor-alpha. Wound.Repair Regen. 14:187-194.
Wandke,C. and S.Geley. 2006. Generation and
characterization of an hKid-specific monoclonal antibody. Hybridoma
(Larchmt.) 25:41-43.
Wolf,F., C.Wandke, N.Isenberg, and S.Geley.
2006. Dose-dependent effects of stable cyclin B1 on progression through mitosis
in human cells. EMBO J. 25:2802-2813.
2005
Ausserlechner,M.J., P.Obexer, S.Geley, and
R.Kofler. 2005. G1 arrest by P16INK4A uncouples growth from cell
cycle progression in leukemia cells with deregulated cyclin E and c-myc
expression. Leukemia 19:1051-1057.
Parson,W., R.Kirchebner, R.Mühlmann,
K.Renner, A.Kofler, S.Schmidt, and R.Kofler. 2005. Cancer cell line
identification by short tandem repeat profiling: power and limitations. FASEB
J. 19:434-436.
Ploner,C., S.Schmidt, E.Presul, K.Renner,
K.Schröcksnadel, J.Rainer, S.Riml, and R.Kofler. 2005. Glucocorticoid-induced
apoptosis and glucocorticoid resistance in acute lymphoblastic leukemia. J.Steroid
Biochem.Mol.Biol. 93:153-160.
Tzankov,A., A.Zimpfer, P.Went, R.Maurer,
S.A.Pileri, S.Geley, and S.Dirnhofer. 2005. Aberrant expression of cell cycle
regulators in Hodgkin and Reed-Sternberg cells of classical Hodgkin's lymphoma.
Mod.Pathol. 18:90-96.
2004
Ausserlechner,M.J., P.Obexer, G.Böck,
S.Geley, and R.Kofler. 2004. Cyclin D3 and c-myc control glucocorticoid-induced
cell cycle arrest but not apoptosis in lymphoblastic leukemia cells. Cell
Death.Differ. 11:165-174.
Geley,S. and C.Muller. 2004. RNAi: ancient
mechanism with a promising future. Exp.Gerontol. 39:985-998.
Hutter,E., K.Renner, G.Pfister, P.Stockl,
P.Jansen-Durr, and E.Gnaiger. 2004. Senescence-associated changes in
respiration and oxidative phosphorylation in primary human fibroblasts. Biochem.J.
380:919-928.
Riml,S., S.Schmidt, M.J.Ausserlechner,
S.Geley, and R.Kofler. 2004. Glucocorticoid receptor heterozygosity combined
with lack of receptor auto-induction causes glucocorticoid resistance in Jurkat
acute lymphoblastic leukemia cells. Cell Death.Differ. 11 Suppl
1:S65-S72.
Schmidt,S., J.Rainer, C.Ploner, E.Presul,
S.Riml, and R.Kofler. 2004. Glucocorticoid-induced apoptosis and glucocorticoid
resistance: Molecular mechanisms and clinical relevance. Cell Death.Differ.
11 Suppl 1:S45-S55.
Tsurumi,C., S.Hoffmann, S.Geley, R.Graeser,
and Z.Polanski. 2004. The spindle assembly checkpoint is not essential for CSF
arrest of mouse oocytes. J.Cell Biol. 167:1037-1050.
Larcher,C., D.Bernhard, E.Schaadt, B.Adler,
M.J.Ausserlechner, M.Mitterer, and H.P.Huemer. 2003. Functional analysis of the
mutated Epstein-Barr virus oncoprotein LMP1(69del): implications for a new role
of naturally occurring LMP1 variants. Haematologica 88:1324-1335.
Kofler,R., S.Schmidt, A.Kofler, and M.J.Ausserlechner. 2003. Resistance to
glucocorticoid-induced apoptosis in lymphoblastic leukemia. J. Endocrinol.
178:19-27.
Bernhard,D., W.Schwaiger, R.Crazzolara, I.Tinhofer, R.Kofler, and A.Csordas.
2003. Enhanced MTT-reducing activity under growth inhibition by resveratrol in
CEM-C7H2 lymphocytic leukemia cells. Cancer Lett. 195:193-199.
Villunger,A., E.M.Michalak, L.Coultas, F.Mullauer, G.Bock, M.J.Ausserlechner,
J.M.Adams, and A.Strasser. 2003. p53- and drug-induced apoptotic responses
mediated by BH3-only proteins puma and noxa. Science 302:1036-1038.
Tzankov,A., A.Zimpfer, A.Lugli, J.Krugmann, P.Went, P.Schraml, R.Maurer,
S.Ascani, S.Pileri, S.Geley, and S.Dirnhofer. 2003. High-throughput tissue
microarray analysis of G1-cyclin alterations in classical Hodgkin's lymphoma
indicates overexpression of cyclin E1. J. Pathol. 199:201-207.
Renner,K., M.J.Ausserlechner, and R.Kofler. 2003. A conceptual view on
glucocorticoid-induced apoptosis, cell cycle arrest and glucocorticoid
resistance in lymphoblastic leukemia. Curr. Mol. Med. 3:707-717.
Tonko-Geymayer,S., O.Goupille, M.Tonko,
C.Soratroi, A.Yoshimura, C.Streuli, A.Ziemiecki, R.Kofler, and W.Doppler. 2002.
Regulation and function of the cytokine inducible SH-2 domain proteins cis and
socs3 in mammary epithelial cells. Mol. Endocrinol. 16:1680-1695.
Ruefli,A.A., D.Bernhard, K.Tainton, R.Kofler, M.J.Smyth, and R.W.Johnstone.
2002. Suberoylanilide hydroxamic acid (SAHA) overcomes multidrug resistance and
induces cell death in P-gp expressing cells. Int. J. Cancer 99:292-298.
Crazzolara,R., K.Jöhrer, R.W.Johnstone, R.Greil, R.Kofler, B.Meister, and
D.Bernhard. 2002. Histone deacetylase inhibitors potently repress CXCR4
chemokine receptor expression and function in acute lymphoblastic leukemia. Br.
J. Haematol. 119:965-969.
Tonko,M., M.J.Ausserlechner, D.Bernhard,
A.Helmberg, and R.Kofler. 2001. Gene expression profiles of proliferating
versus G1/G0 arrested human leukemia cells suggest a mechanism for
glucocorticoid-induced apoptosis. FASEB J. 15:693-699.
Tinhofer,I., D.Bernhard, M.Senfter, G.Anether, M.Loeffler, G.Kroemer, R.Kofler,
A.Csordas, and R.Greil. 2001. Resveratrol, a tumor-suppressive compound from
grapes, induces apoptosis via a novel mitochondrial pathway controlled by
Bcl-2. FASEB J. 9:1613-1615.
Tiefenthaler,M., A.Amberger, N.Bacher, B.L.Hartmann, R.Margreiter, R.Kofler,
and G.Konwalinka. 2001. Increased lactate production follows loss of
mitochondrial membrane potential during apoptosis of human leukaemia cells. Br.
J. Haematol. 114:574-580.
Ruefli,A.A., M.J.Ausserlechner, D.Bernhard, V.R.Sutton, K.M.Tainton, R.Kofler,
M.J.Smyth, and R.W.Johnstone. 2001. The histone deacetylase inhibitor and
chemotherapeutic agent suberoylanilide hydroxamic acid (SAHA) induces a
cell-death pathway characterized by cleavage of Bid and production of reactive
oxygen species. Proc. Natl. Acad. Sci. U. S. A. 98:10833-10838.
Pallis,M., M.Grundy, J.Turzanski, R.Kofler, and N.Russel. 2001. Mitochondrial
membrane sensitivity to depolarization in acute myeloblastic leukaemia is
associated with spontaneous in vitro apoptosis, wild-type TP53 and vicinal
thiol/disulphide status. Blood 98:405-413.
Obexer,P., U.Certa, R.Kofler, and A.Helmberg. 2001. Expression profiling of
glucocorticoid-treated T-ALL cell lines: rapid repression of multiple genes
involved in RNA-, protein- and nucleotide synthesis. Oncogene 20:4324-4336.
Helmberg,A. 2001. DNA-microarrays: novel techniques to study aging and guide gerontologic
medicine. Exp. Gerontol. 36:1189-1198.
Bernhard,D., S.Skvortsov, I.Tinhofer, H.Hübl, R.Greil, A.Csordas, and R.Kofler.
2001. Inhibition of histone deacetylase activity enhances fas-induced apoptosis
in leukemic lymphoblasts. Cell Death Differ. 8:1014-1021.
Wagner,M., B.Hampel, D.Bernhard, M.Hala, W.Zwerschke, and P.Jansen-Durr. 2001.
Replicative senescence of human endothelial cells in vitro involves G1 arrest,
polyploidization and senescence-associated apoptosis. Exp. Gerontol.
36:1327-1347.
Ausserlechner,M.J., P.Obexer, G.J.Wiegers, B.L.Hartmann, S.Geley, and R.Kofler.
2001. The cell cycle inhibitor p16/INK4A sensitizes lymphoblastic leukemia
cells to apoptosis by physiologic glucocorticoid levels. J. Biol. Chem.
276:10984-10989.
Kuhr,T., O.Bechter, S.Dirnhofer, S.Geley,
A.Gachter, G.Pall, M.Url, H.Dietrich, P.Oberaigner, G.Klima, W.Eisterer,
W.Hilbe, P.Lukas, and J.Thaler. 2000. Transplantation of IL-2-transduced murine
bone marrow is associated with dose-dependent toxicity. Exp. Hematol.
28:895-906.
Bernhard,D., I.Tinhofer, M.Tonko, H.Hübl, M.J.Ausserlechner, R.Greil, R.Kofler,
and A.Csordas. 2000. Resveratrol causes arrest in the S-phase prior to
fas-independent apoptosis in CEM-C7H2 acute leukemia cells. Cell Death Differ.
7:834-842.
Kofler,R. 2000. The molecular basis of glucocorticoid-induced apoptosis of
lymphoblastic leukemia cells. Histochem. Cell Biol. 114:1-7.